Multi-therapeutic strategy targeting Akt-mTOR and FoxO1 pathway to counteract skeletal muscle atrophy consecutive to hypoxia

• Published in: American Journal of Physiology: Cell Physiology Vol. 328; no. 6; pp. C2057 - C2069
• Main Authors: Bensaid, Samir, Fabre, Claudine, Yahya Rajaei, Amir, Claeyssen, Charlotte, Daussin, Frédéric N., Cieniewski-Bernard, Caroline
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2025
• Series: American Journal of Physiology - Cell Physiology
• Subjects: AKT protein; Altitude; Amino acids; Animals; Atrophy; Atrophy - drug therapy; Atrophy - genetics; Atrophy - metabolism; Atrophy - pathology; Cell activation; Cell Hypoxia; Cell Line; Dietary supplements; DNA damage; Electrical stimuli; Forkhead Box Protein O1 - genetics; Forkhead Box Protein O1 - metabolism; Forkhead protein; FOXO1 protein; Glycogen; Glycogen synthase kinase 3; Hypoxemia; Hypoxia; Kinases; Life Sciences; Mice; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscular Diseases - drug therapy; Muscular Diseases - genetics; Muscular Diseases - metabolism; Muscular Diseases - pathology; Musculoskeletal system; Myostatin; Myotubes; Oxygen; Oxygenation; Phosphorylation; Physical activity; Physiology; Proteasomes; Protein biosynthesis; Proteins; Proteolysis; Proto-Oncogene Proteins c-akt - metabolism; Rapamycin; Signal Transduction; Skeletal muscle; TOR Serine-Threonine Kinases - metabolism; hypoxia; signaling pathways; skeletal muscle; protein homeostasis

Our research demonstrates that combining electrical stimulation, BCAA supplementation, and oxygenation effectively counteracts hypoxia-induced muscle atrophy. Unlike isolated treatments, this multi-therapy approach significantly improves myotube morphology and regulates key protein homeostasis pathw...