Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension

• Published in: Journal of applied physiology (1985) Vol. 138; no. 1; pp. 182 - 194
• Main Authors: Leite, Luciano Bernardes, Soares, Leôncio Lopes, Portes, Alexandre Martins Oliveira, da Silva, Bruna Aparecida Fonseca, Dias, Taís Rodrigues, Soares, Thayana Inácia, Assis, Mirian Quintão, Guimarães-Ervilha, Luiz Otávio, Carneiro-Júnior, Miguel Araújo, Forte, Pedro, Machado-Neves, Mariana, Reis, Emily Correna Carlo, Natali, Antônio José
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2025
• Subjects: Acceleration; Alveoli; Amplitudes; Animals; Calcium (intracellular); Calcium ions; Carbonyl compounds; Carbonyls; Cardiomyocytes; Catalase; Disease Progression; Exercise; Extracellular matrix; Fitness training programs; Glutathione; Glutathione transferase; Heart; Heart Ventricles - metabolism; Heart Ventricles - physiopathology; Hypertension; Hypertension, Pulmonary - chemically induced; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - physiopathology; Load resistance; Lung - metabolism; Lung - physiopathology; Lungs; Male; Monocrotaline; Myocytes; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Nitric oxide; Oxidative stress; Oxidative Stress - physiology; Physical Conditioning, Animal - physiology; Physical exercise; Physical training; Physiology; Pulmonary Arterial Hypertension - chemically induced; Pulmonary Arterial Hypertension - metabolism; Pulmonary Arterial Hypertension - physiopathology; Pulmonary arteries; Pulmonary artery; Pulmonary Artery - metabolism; Pulmonary Artery - physiopathology; Pulmonary hypertension; Rats; Rats, Wistar; Running; Structure-function relationships; Ventricular Function, Right - physiology; Ventricular Remodeling - physiology; Vertical loads; combined exercise training; remodeling; isolated myocytes; pulmonary arterial hypertension; oxidative stress

This study reveals that combined exercise improves tolerance to physical effort, prevents increases in pulmonary artery resistance, and conserves the right heart function during the progression of pulmonary arterial hypertension. Our analyses show that combined exercise hinders harmful right ventric...