Unsaturated Fatty Acids Increase the Expression of Hepassocin through a Signal Transducer and Activator of Transcription 3‐Dependent Pathway in HepG2 Cells

• Published in: Lipids Vol. 53; no. 9; pp. 863 - 869
• Main Authors: Cheng, Kai‐Pi, Ou, Horng‐Yih, Hung, Hao‐Chang, Li, Chung‐Hao, Fan, Kang‐Chih, Wu, Jin‐Shang, Wu, Hung‐Tsung, Chang, Chih‐Jen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2018
• Subjects: cell culture; cell viability; Fatty Acids, Unsaturated - pharmacology; fatty liver; Hep G2 Cells; Hepassocin; Hepatic steatosis; Humans; interleukin-6; linoleic acid; Neoplasm Proteins - biosynthesis; Oleic acid; palmitic acid; promoter regions; protective effect; RNA; Signal transducer and activator of transcription 3; signal transduction; Signal Transduction - drug effects; STAT3 Transcription Factor - metabolism; stearic acid; transactivators; transfection; Tumor Cells, Cultured; Unsaturated fatty acids; Unsaturated fatty acids; Hepassocin; Hepatic steatosis; Oleic acid; Signal transducer and activator of transcription 3

Hepassocin (HPS) is a hepatokine that regulates hepatocyte proliferation. It is known that HPS plays an important role in the development of nonalcoholic fatty liver diseases (NAFLD). Fatty acids, such as oleic acid (OLA), exhibit the ability to activate the signal transducer and activator of transc...