Selective action of human sera differing in fatty acids and cholesterol content on in vitro gene expression

• Published in: Journal of cellular biochemistry Vol. 113; no. 3; pp. 815 - 823
• Main Authors: Zirpoli, Hylde, Caputo, Mariella, Carraturo, Antonio, Torino, Gaetano, Fazio, Alessia, Attya, Mohamed, Rastrelli, Luca, Tecce, Mario Felice
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2012
• Subjects: Adult; Cell Line, Tumor; CHOLESTEROL; Cholesterol - blood; DOCOSAHEXANEOIC ACID; EICOSOPENTANOIC ACID; Fatty Acids - blood; GENE EXPRESSION; Glucuronosyltransferase - genetics; Glucuronosyltransferase - metabolism; Humans; Hypercholesterolemia - blood; Ion Channels - genetics; Ion Channels - metabolism; Male; Middle Aged; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; POLYUNSATURATED FATTY ACIDS; RNA, Messenger - metabolism; Serum - chemistry; SERUM LIPIDS; Stearoyl-CoA Desaturase - genetics; Stearoyl-CoA Desaturase - metabolism; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Uncoupling Protein 2

Serum constituents might directly affect metabolic diseases pathogenesis and are commonly used as diagnostic tool. The aim of this study was to investigate the human serum effect on in vitro gene expression, related to nutrients action and involved in lipid metabolism. In detail, 40 human sera were...