Role of statins in the management of dyslipidaemia

Blood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm r...

Full description

Saved in:
Bibliographic Details
Published inIndian heart journal Vol. 76; no. Suppl 1; pp. S33 - S37
Main Author Ray, Saumitra
Format Journal Article
LanguageEnglish
Published Elsevier, a division of RELX India, Pvt. Ltd 01.03.2024
Elsevier
Subjects
Atherosclerotic cardiovascular disease
Cholesterol
Familial hypercholesterolemia
Metabolic syndrome
Review
Statin
Statin
Familial hypercholesterolemia
Atherosclerotic cardiovascular disease
Metabolic syndrome
Cholesterol
Online AccessGet full text

Cover

More Information
Summary:Blood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Also, they are very safe and well tolerated. As ASCVD comes in various stages, statins have also been tried in different settings, e.g., primary prevention, secondary prevention, as part of coronary intervention strategy, familial hypercholesterolemia, etc. Almost in all clinical scenarios, statins proved themselves to impart clinical benefit. Though side effects of statins are outweighed by their benefits, nonetheless clinicians should detect the side effects early to avoid major problems.
ISSN:0019-4832
2213-3763
DOI:10.1016/j.ihj.2023.11.267