Use of monocyte/endothelial cell co-cultures (in vitro) and a subcutaneous implant mouse model (in vivo) to evaluate a degradable polar hydrophobic ionic polyurethane

• Published in: Journal of cellular biochemistry Vol. 112; no. 12; pp. 3762 - 3772
• Main Authors: McDonald, Sarah M., Matheson, Loren A., McBane, Joanne E., Kuraitis, Drew, Suuronen, Erik, Santerre, Joseph Paul, Labow, Rosalind S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2011
• Subjects: Animals; Biocompatible Materials; Blood Vessel Prosthesis; Blotting, Western; Co-culture; Coculture Techniques; Cytokines - metabolism; Endothelial cell; Endothelium, Vascular - cytology; Endothelium, Vascular - metabolism; Enzyme-Linked Immunosorbent Assay; Female; Humans; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Models, Animal; Monocyte/macrophage; Monocytes - cytology; Monocytes - metabolism; Polyurethane; Polyurethanes - metabolism; Scaffold implant; Vascular graft

Potential benefits of co‐culturing monocytes (MC) with vascular smooth muscle cells have been reported on for tissue engineering applications with a degradable, polar, hydrophobic, and ionic polyurethane (D‐PHI). Since the interaction of MC and endothelial cells (EC) within the blood vessel endothel...