Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line

• Published in: The Journal of biological chemistry Vol. 293; no. 26; pp. 10333 - 10343
• Main Authors: Tachibana, Keisuke, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Maegawa, Takashi, Takahashi, Rika, Tanimoto, Keiichi, Tsujino, Hirofumi, Nunomura, Kazuto, Lin, Bangzhong, Matsuura, Yoshiharu, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Kobayashi, Tadayuki, Ishimoto, Kenji, Miyachi, Hiroyuki, Doi, Takefumi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.06.2018; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; cell biology; chemical screening system; Drug Evaluation, Preclinical; drug screening; dyslipidemia; Fructose - adverse effects; Gene Expression Regulation - drug effects; Gene Regulation; Genes, Reporter - genetics; Humans; Hypolipidemic Agents - pharmacology; ligand; Ligands; nuclear receptor; peroxisome proliferator-activated receptor (PPAR); PPAR alpha - genetics; PPAR alpha - metabolism; Rats; Tet-off system; transcription regulation; triglyceride; peroxisome proliferator-activated receptor (PPAR); triglyceride; transcription regulation; cell biology; drug screening; chemical screening system; Tet-off system; nuclear receptor; dyslipidemia; ligand

Peroxisome proliferator–activated receptor α (PPARα) is a ligand-activated transcription factor that belongs to the superfamily of nuclear hormone receptors. PPARα is mainly expressed in the liver, where it activates fatty acid oxidation and lipoprotein metabolism and improves plasma lipid profiles....