What Should we do When HIV-Positive Children Fail First-Line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies

• Published in: The Pediatric infectious disease journal
• Main Authors: Patten, Gabriela, Schomaker, Michael, Davies, Mary-Ann, Rabie, Helena, van Zyl, Gert, Technau, Karl, Eley, Brian, Boulle, Andrew, Van Dyke, Russell B, Patel, Kunjal, Sipambo, Nosisa, Wood, Robin, Tanser, Frank, Giddy, Janet, Cotton, Mark, Nuttall, James, Essack, Gadija, Karalius, Brad, Seage, lll, George, Sawry, Shobna, Egger, Matthias, Fairlie, Lee
• Format: Journal Article
• Language: English
• Published: United States 01.04.2019

Managing virologic failure (VF) in HIV-infected children is especially difficult in resource-limited settings, given limited availability of alternative drugs, concerns around adherence and the development of HIV resistance mutations. We aimed to evaluate four management strategies for children foll...