Application of the instrumental inequalities to a Mendelian randomization study with multiple proposed instruments

• Published in: Epidemiology (Cambridge, Mass.)
• Main Authors: Diemer, Elizabeth W, Labrecque, Jeremy, Tiemeier, Henning, Swanson, Sonja A
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020

Investigators often support the validity of Mendelian randomization (MR) studies, an instrumental variable approach proposing genetic variants as instruments, via subject matter knowledge. However, the instrumental variable model implies certain inequalities, offering an empirical method of falsifyi...