Short‐Chain Fatty Acids Enhance the Lipid Accumulation of 3T3‐L1 Cells by Modulating the Expression of Enzymes of Fatty Acid Metabolism

• Published in: Lipids Vol. 53; no. 1; pp. 77 - 84
• Main Authors: Yu, Haining, Li, Ran, Huang, Haiyong, Yao, Ru, Shen, Shengrong
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2018
• Subjects: 3T3-L1 Cells; 3T3‐L1 cell; acetic acid; Acetic Acid - chemistry; Acetic Acid - metabolism; acid treatment; adipocytes; Adipocytes - metabolism; Adipogenesis - genetics; Animals; butyric acid; Butyric Acid - chemistry; Butyric Acid - metabolism; Cell Differentiation - genetics; Fatty acid metabolism; Fatty Acid Synthases - genetics; Fatty Acid Synthases - metabolism; fatty acid transport proteins; Fatty Acid Transport Proteins - genetics; Fatty Acid-Binding Proteins - genetics; Fatty Acids, Volatile - genetics; Fatty Acids, Volatile - metabolism; fatty-acid synthase; fermentation; Gastrointestinal Microbiome - genetics; Gene Expression Regulation, Enzymologic; Gut microbiota; intestinal microorganisms; Lipid accumulation; lipid content; Lipid Metabolism - genetics; lipoprotein lipase; Lipoprotein Lipase - genetics; Mice; Propionates - chemistry; Propionates - metabolism; propionic acid; Short chain fatty acids; toxicity testing; triacylglycerols; Triglycerides - metabolism; viability; Western blotting; Gut microbiota; Lipid accumulation; 3T3-L1 cell; Fatty acid metabolism; Short chain fatty acids

Short‐chain fatty acids (SCFA) such as acetic acid, propionic acid, and butyric acid are produced by fermentation by gut microbiota. In this paper, we investigate the effects of SCFA on 3T3‐L1 cells and the underlying molecular mechanisms. The cells were treated with acetic acid, propionic acid, or...