Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits

• Published in: Nature metabolism Vol. 3; no. 7; pp. 940 - 953
• Main Authors: Salisbury, David A, Casero, David, Zhang, Zhengyi, Wang, Dan, Kim, Jason, Wu, Xiaohui, Vergnes, Laurent, Mirza, Aashiq H, Leon-Mimila, Paola, Williams, Kevin J, Huertas-Vazquez, Adriana, Jaffrey, Samie R, Reue, Karen, Chen, Jianjun, Sallam, Tamer
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.07.2021
• Subjects: Bcl-6 protein; Diet; Enzymatic activity; Experiments; Fatty acids; Fatty liver; Females; Gene expression; Gene regulation; Lipid composition; Lipid metabolism; Lipids; Liver; Males; Metabolism; Methylation; Morbidity; N6-methyladenosine; Proteins; RNA modification; Sex; Sex differences; Stat5 protein; Steatosis; Variance analysis

Males and females exhibit striking differences in the prevalence of metabolic traits including hepatic steatosis, a key driver of cardiometabolic morbidity and mortality. RNA methylation is a widespread regulatory mechanism of transcript turnover. Here, we show that presence of the RNA modification...