Synthesis of Cyclic Bis(3′-5′)-2′-deoxyguanylic/guanylic Acid (c-dGpGp) and Its Biological Activities to Microbes

• Published in: ChemMedChem Vol. 2; no. 10; pp. 1410 - 1413
• Main Authors: Mano, Erina, Hyodo, Mamoru, Sato, Yumi, Ishihara, Yuka, Ohta, Michio, Hayakawa, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 08.10.2007; WILEY‐VCH Verlag
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Biofilms; biological activity; c-di-GMP; Guanosine Monophosphate - analogs & derivatives; Guanosine Monophosphate - chemical synthesis; Guanosine Monophosphate - chemistry; Guanosine Monophosphate - pharmacology; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; nucleotides; structure-activity relationships
• ISSN: 1860-7179; 1860-7187
• DOI: 10.1002/cmdc.200700072

c‐di‐GMP is considered to play an important role in regulating exopolysaccharide production, biofilm formation, and other phenotypes in bacteria. These attractive biological properties of c‐di‐GMP prompted us to carry out a systematic study of the bioactivity of c‐di‐GMP‐related compounds, including derivatives with modified nucleoside bases, carbohydrates, or internucleotide bonds. Synthesis of c‐dGpGp and its biological activities is reported.