Calcium Channel TRPV6 Expression in Human Duodenum: Different Relationships to the Vitamin D System and Aging in Men and Women

• Published in: Journal of bone and mineral research Vol. 21; no. 11; pp. 1770 - 1777
• Main Authors: Walters, Julian RF, Balesaria, Sara, Chavele, Konstantia‐Maria, Taylor, Vivienne, Berry, Jacqueline L, Khair, Umma, Barley, Natalie F, van Heel, David A, Field, Jennifer, Hayat, Jamal O, Bhattacharjee, Abhik, Jeffery, Rosemary, Poulsom, Richard
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.11.2006
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Base Sequence; Calcium - metabolism; Duodenum - metabolism; Female; Gene Expression Regulation; Humans; Ileum - metabolism; ion transport; Male; menopause; Middle Aged; Molecular Sequence Data; nutrition; Receptors, Calcitriol - metabolism; Sex Factors; TRPV Cation Channels - metabolism; TRPV Cation Channels - physiology; vitamin D; Vitamin D - metabolism

Intestinal absorption of calcium affects bone mineralization and varies greatly. In human duodenum, expression of the calcium channel TRPV6 was directly related to blood 1,25‐dihydroxyvitamin D in men, but effects of age with lower median vitamin D receptor levels were more significant in women. Int...