Non-invasive cryolipolysis™ for subcutaneous fat reduction does not affect serum lipid levels or liver function tests
Background and Objective Cryolipolysis provides a method of non‐invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study...
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| Published in | Lasers in surgery and medicine Vol. 41; no. 10; pp. 785 - 790 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Background and Objective
Cryolipolysis provides a method of non‐invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study was intended to more fully document any effect of this procedure on lipid and liver‐related blood tests.
Study Design/Materials and Methods
Forty subjects with fat bulges on their flanks (“love handles”) were treated bilaterally with a non‐invasive device (Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a reduction in the fat layer. Serum lipid levels and liver tests were measured prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post‐treatment.
Results
No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12‐week follow‐up period.
Conclusion
Cryolipolysis, when used for reduction of subcutaneous flank fat, is not associated with changes in serum lipids or liver test results. Lasers Surg. Med. 41:785–790, 2009. © 2009 Wiley‐Liss, Inc. |
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| AbstractList | Background and Objective
Cryolipolysis provides a method of non‐invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study was intended to more fully document any effect of this procedure on lipid and liver‐related blood tests.
Study Design/Materials and Methods
Forty subjects with fat bulges on their flanks (“love handles”) were treated bilaterally with a non‐invasive device (Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a reduction in the fat layer. Serum lipid levels and liver tests were measured prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post‐treatment.
Results
No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12‐week follow‐up period.
Conclusion
Cryolipolysis, when used for reduction of subcutaneous flank fat, is not associated with changes in serum lipids or liver test results. Lasers Surg. Med. 41:785–790, 2009. © 2009 Wiley‐Liss, Inc. Cryolipolysis provides a method of non-invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study was intended to more fully document any effect of this procedure on lipid and liver-related blood tests.BACKGROUND AND OBJECTIVECryolipolysis provides a method of non-invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study was intended to more fully document any effect of this procedure on lipid and liver-related blood tests.Forty subjects with fat bulges on their flanks ("love handles") were treated bilaterally with a non-invasive device (Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a reduction in the fat layer. Serum lipid levels and liver tests were measured prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post-treatment.STUDY DESIGN/MATERIALS AND METHODSForty subjects with fat bulges on their flanks ("love handles") were treated bilaterally with a non-invasive device (Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a reduction in the fat layer. Serum lipid levels and liver tests were measured prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post-treatment.No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12-week follow-up period.RESULTSNo meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12-week follow-up period.Cryolipolysis, when used for reduction of subcutaneous flank fat, is not associated with changes in serum lipids or liver test results.CONCLUSIONCryolipolysis, when used for reduction of subcutaneous flank fat, is not associated with changes in serum lipids or liver test results. Cryolipolysis provides a method of non-invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary animal and human data have suggested that cryolipolysis has no effect on serum lipid profiles or liver tests. This study was intended to more fully document any effect of this procedure on lipid and liver-related blood tests. Forty subjects with fat bulges on their flanks ("love handles") were treated bilaterally with a non-invasive device (Zeltiq Aesthetics, Pleasanton, CA) that precisely cools tissue to achieve a reduction in the fat layer. Serum lipid levels and liver tests were measured prior to treatment, and at 1 day and 1, 4, 8, and 12 weeks post-treatment. No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12-week follow-up period. Cryolipolysis, when used for reduction of subcutaneous flank fat, is not associated with changes in serum lipids or liver test results. |
| Author | Okamoto, Eric Zelickson, Brian Klein, Kenneth B. Harry, Rosemary S. Bachelor, Eric P. Preciado, Jessica A. Riopelle, Jeffrey G. |
| Author_xml | – sequence: 1 givenname: Kenneth B. surname: Klein fullname: Klein, Kenneth B. organization: Endpoint LLC, Bainbridge Island, Washington 98110 – sequence: 2 givenname: Brian surname: Zelickson fullname: Zelickson, Brian organization: Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 – sequence: 3 givenname: Jeffrey G. surname: Riopelle fullname: Riopelle, Jeffrey G. organization: Laser Advantage Medi-Spa of San Ramon, San Ramon, California 94583 – sequence: 4 givenname: Eric surname: Okamoto fullname: Okamoto, Eric organization: Fremont Plastic Surgery, Fremont, California 94538 – sequence: 5 givenname: Eric P. surname: Bachelor fullname: Bachelor, Eric P. organization: The Plastic Surgery Center, Pleasanton, California 94566 – sequence: 6 givenname: Rosemary S. surname: Harry fullname: Harry, Rosemary S. organization: RHarry Consulting, Killingworth, Connecticut 06419 – sequence: 7 givenname: Jessica A. surname: Preciado fullname: Preciado, Jessica A. email: jpreciado@zeltiq.com organization: Zeltiq Aesthetics, Pleasanton, California 94588 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20014252$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s0026601-0034-6 10.1007/s11695-007-9261-5 10.1016/j.metabol.2006.05.004 10.1007/s00266-008-9286-8 10.1111/j.1524-4725.2009.01259.x 10.1002/lsm.20719 10.3949/ccjm.75.10.721 10.1093/clinchem/41.10.1414 10.1016/S0899-9007(00)00381-6 10.1016/j.cryobiol.2008.10.060 10.1007/s00266-005-0010-7 |
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| Notes | ark:/67375/WNG-VHFPT8RR-T Disclosures: Dr. Kenneth Klein, Dr. Brian Zelickson, and Rosemary Harry are paid consultants to Zeltiq Aesthetics. Drs. Jeffrey Riopelle, Eric Okamoto, and Eric Bachelor received compensation for participation as study investigators. Dr. Jessica Preciado is an employee of Zeltiq Aesthetics. Zeltiq Aesthetics istex:058CE7A4A431E7ED877D0CDFA706ACE11C01A553 ArticleID:LSM20850 Disclosures Dr. Kenneth Klein, Dr. Brian Zelickson, and Rosemary Harry are paid consultants to Zeltiq Aesthetics. Drs. Jeffrey Riopelle, Eric Okamoto, and Eric Bachelor received compensation for participation as study investigators. Dr. Jessica Preciado is an employee of Zeltiq Aesthetics. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| References | Dover J, Burns J, Coleman S, Fitzpatrick R, Garden J, Goldberg D, Geronemus R, Kilmer S, Mayoral F, Tanzi E, Weiss R, Zelickson B. A prospective clinical study of noninvasive cryolipolysis for subcutaneous fat layer reduction-Interim report of available subject data. Lasers Surg Med 2009; 41(S21): 43. Nordenstrom J, Thorne A, Aberg W, et al. The hypertriglyceridemic clamp technique. Studies using long-chain and structured triglyceride emulsions in health subjects. Metab Clin Exp 2006; 55: 1443-1450. Zelickson B, Egbert BM, Preciado J, Allison J, Springer K, Manstein D. Cryolipolysis for noninvasive fat cell destruction: Initial results from a pig model. Dermatol Surg 2009; 35(10): 1462-1470. Preciado JA, Allison JW. The effect of cold exposure on adipocytes: Examining a novel method for the noninvasive removal of fat. Cryobiology 2008; 57: 327. Crook MA. Lipid clearance and total parenteral nutrition: The importance of monitoring plasma lipids. Nutrition 2000; 16: 774-775. Vandeweyer E. Does liposuction influence lipidogram in females: In-vivo study. Aesthetic Plast Surg 2002; 26: 17-19. Ybarra J, Blanco-Vaca F, Fernandez S, et al. The effects of liposuction removal of subcutaneous abdominal fat on lipid metabolism are independent of insulin sensitivity in normal-overweight individuals. Obes Surg 2008; 18: 408-414. Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J. Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves. Aesthetic Plast Surg 2009; 33: 482-488. Kim CH, Younossi ZM. Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome. Cleve Clin J Med 2008; 75: 721-728. Hong YG, Kim HT, Seo SW, et al. Impact of large-volume liposuction on serum lipids in Orientals: A pilot study. Aesthetic Plast Surg 2006; 30: 327-332. Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR. Selective cryolysis: A novel method of non-invasive fat removal. Lasers Surg Med 2008; 40: 595-604. 2009; 33 2009; 35 2002; 26 2009; 41 2006; 30 2000; 16 2006; 55 2008; 18 2009 2008; 57 1995 2008; 75 2008; 40 Dover J (e_1_2_1_5_2) 2009; 41 e_1_2_1_6_2 e_1_2_1_7_2 e_1_2_1_4_2 e_1_2_1_2_2 e_1_2_1_11_2 e_1_2_1_3_2 e_1_2_1_12_2 e_1_2_1_10_2 e_1_2_1_13_2 e_1_2_1_14_2 e_1_2_1_8_2 e_1_2_1_9_2 |
| References_xml | – reference: Zelickson B, Egbert BM, Preciado J, Allison J, Springer K, Manstein D. Cryolipolysis for noninvasive fat cell destruction: Initial results from a pig model. Dermatol Surg 2009; 35(10): 1462-1470. – reference: Nordenstrom J, Thorne A, Aberg W, et al. The hypertriglyceridemic clamp technique. Studies using long-chain and structured triglyceride emulsions in health subjects. Metab Clin Exp 2006; 55: 1443-1450. – reference: Kim CH, Younossi ZM. Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome. Cleve Clin J Med 2008; 75: 721-728. – reference: Crook MA. Lipid clearance and total parenteral nutrition: The importance of monitoring plasma lipids. Nutrition 2000; 16: 774-775. – reference: Preciado JA, Allison JW. The effect of cold exposure on adipocytes: Examining a novel method for the noninvasive removal of fat. Cryobiology 2008; 57: 327. – reference: Dover J, Burns J, Coleman S, Fitzpatrick R, Garden J, Goldberg D, Geronemus R, Kilmer S, Mayoral F, Tanzi E, Weiss R, Zelickson B. A prospective clinical study of noninvasive cryolipolysis for subcutaneous fat layer reduction-Interim report of available subject data. Lasers Surg Med 2009; 41(S21): 43. – reference: Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR. Selective cryolysis: A novel method of non-invasive fat removal. Lasers Surg Med 2008; 40: 595-604. – reference: Hong YG, Kim HT, Seo SW, et al. Impact of large-volume liposuction on serum lipids in Orientals: A pilot study. Aesthetic Plast Surg 2006; 30: 327-332. – reference: Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J. Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves. Aesthetic Plast Surg 2009; 33: 482-488. – reference: Vandeweyer E. Does liposuction influence lipidogram in females: In-vivo study. Aesthetic Plast Surg 2002; 26: 17-19. – reference: Ybarra J, Blanco-Vaca F, Fernandez S, et al. The effects of liposuction removal of subcutaneous abdominal fat on lipid metabolism are independent of insulin sensitivity in normal-overweight individuals. Obes Surg 2008; 18: 408-414. – year: 2009 – volume: 75 start-page: 721 year: 2008 end-page: 728 article-title: Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome publication-title: Cleve Clin J Med – volume: 55 start-page: 1443 year: 2006 end-page: 1450 article-title: The hypertriglyceridemic clamp technique. Studies using long‐chain and structured triglyceride emulsions in health subjects publication-title: Metab Clin Exp – volume: 40 start-page: 595 year: 2008 end-page: 604 article-title: Selective cryolysis: A novel method of non‐invasive fat removal publication-title: Lasers Surg Med – volume: 35 start-page: 1462 issue: 10 year: 2009 end-page: 1470 article-title: Cryolipolysis for noninvasive fat cell destruction: Initial results from a pig model publication-title: Dermatol Surg – year: 1995 – volume: 30 start-page: 327 year: 2006 end-page: 332 article-title: Impact of large‐volume liposuction on serum lipids in Orientals: A pilot study publication-title: Aesthetic Plast Surg – volume: 41 start-page: 43 issue: S21 year: 2009 article-title: A prospective clinical study of noninvasive cryolipolysis for subcutaneous fat layer reduction—Interim report of available subject data publication-title: Lasers Surg Med – volume: 18 start-page: 408 year: 2008 end-page: 414 article-title: The effects of liposuction removal of subcutaneous abdominal fat on lipid metabolism are independent of insulin sensitivity in normal‐overweight individuals publication-title: Obes Surg – volume: 57 start-page: 327 year: 2008 article-title: The effect of cold exposure on adipocytes: Examining a novel method for the noninvasive removal of fat publication-title: Cryobiology – volume: 33 start-page: 482 year: 2009 end-page: 488 article-title: Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves publication-title: Aesthetic Plast Surg – volume: 26 start-page: 17 year: 2002 end-page: 19 article-title: Does liposuction influence lipidogram in females: In‐vivo study publication-title: Aesthetic Plast Surg – volume: 16 start-page: 774 year: 2000 end-page: 775 article-title: Lipid clearance and total parenteral nutrition: The importance of monitoring plasma lipids publication-title: Nutrition – ident: e_1_2_1_10_2 doi: 10.1007/s0026601-0034-6 – ident: e_1_2_1_14_2 doi: 10.1007/s11695-007-9261-5 – ident: e_1_2_1_12_2 doi: 10.1016/j.metabol.2006.05.004 – volume: 41 start-page: 43 issue: 21 year: 2009 ident: e_1_2_1_5_2 article-title: A prospective clinical study of noninvasive cryolipolysis for subcutaneous fat layer reduction—Interim report of available subject data publication-title: Lasers Surg Med – ident: e_1_2_1_6_2 doi: 10.1007/s00266-008-9286-8 – ident: e_1_2_1_3_2 doi: 10.1111/j.1524-4725.2009.01259.x – ident: e_1_2_1_7_2 – ident: e_1_2_1_2_2 doi: 10.1002/lsm.20719 – ident: e_1_2_1_8_2 doi: 10.3949/ccjm.75.10.721 – ident: e_1_2_1_9_2 doi: 10.1093/clinchem/41.10.1414 – ident: e_1_2_1_11_2 doi: 10.1016/S0899-9007(00)00381-6 – ident: e_1_2_1_4_2 doi: 10.1016/j.cryobiol.2008.10.060 – ident: e_1_2_1_13_2 doi: 10.1007/s00266-005-0010-7 |
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| Snippet | Background and Objective
Cryolipolysis provides a method of non‐invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent... Cryolipolysis provides a method of non-invasive fat reduction that significantly reduces subcutaneous fat without injury to adjacent tissues. Preliminary... |
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| SubjectTerms | Adult Aged body contouring Cosmetic Techniques cryolipolysis Cryotherapy fat reduction Female Humans lipids Lipids - blood Liver Function Tests Male Middle Aged Subcutaneous Fat, Abdominal Young Adult |
| Title | Non-invasive cryolipolysis™ for subcutaneous fat reduction does not affect serum lipid levels or liver function tests |
| URI | https://api.istex.fr/ark:/67375/WNG-VHFPT8RR-T/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Flsm.20850 https://www.ncbi.nlm.nih.gov/pubmed/20014252 https://www.proquest.com/docview/733608142 |
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