Treatment of infection due to penicillinase-producing Neisseria gonorrhoeae with oral thiamphenicol and with oral lymecycline

• Published in: Sexually transmitted diseases Vol. 13; no. 3; p. 156
• Main Authors: Latif, A S, Marowa, E, Mason, P R, Sithole, J, Tambo, J, Dhamu, F, Paraiwa, E
• Format: Journal Article
• Language: English
• Published: United States 01.07.1986
• Subjects: Clinical Trials as Topic; Gonorrhea - drug therapy; Humans; Lymecycline - therapeutic use; Male; Neisseria gonorrhoeae - enzymology; Penicillinase - biosynthesis; Tetracyclines - therapeutic use; Thiamphenicol - therapeutic use; Urethritis - drug therapy

Seventy-five men with gonococcal urethritis were treated with a single oral dose of thiamphenicol, and 88 men with this infection were treated with two 1.5-g oral doses of lymecycline taken 12 hr apart. Of the 75 subjects treated with thiamphenicol, 72 (96%) were cured, as compared with 80 (91%) tre...