The Importance of Bacterial Superantigens Produced by Staphylococcus aureus in the Treatment of Atopic Dermatitis Using Povidone-Iodine
Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81...
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| Published in | Dermatology (Basel) Vol. 212; no. Suppl 1; pp. 26 - 34 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Basel, Switzerland
S. Karger AG
01.01.2006
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| Abstract | Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens. |
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| AbstractList | Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens. Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens. [PUBLICATION ABSTRACT] Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens. Copyright [copy 2006 S. Karger AG, Basel |
| Author | Ishikawa, Nobuyasu Kitukawa, Yoshio Kubosawa, Hitoshi Sugimoto, Kazuo Ito, Shoichi Hattori, Takamichi Terano, Takashi |
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| Keywords | Povidone-iodine Bacterial superantigen Antitoxin IgE antibody Disinfection therapy Atopic dermatitis |
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| SubjectTerms | Adolescent Adult Anti-Infective Agents, Local - administration & dosage Antigens Antitoxins - immunology Bacteria Bacterial Toxins - immunology Cervical Vertebrae Child Dermatitis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Drug Resistance, Bacterial Duodenitis - drug therapy Duodenitis - immunology Female Humans Immunoglobulin E - immunology Male Povidone-Iodine - administration & dosage Skin diseases Skin Disinfection Spinal Cord Diseases - drug therapy Spinal Cord Diseases - immunology Spinal Diseases - drug therapy Spinal Diseases - immunology Staphylococcal Infections - drug therapy Staphylococcal Infections - immunology Staphylococcus aureus Staphylococcus aureus - immunology Superantigens - immunology Toxins Treatment Outcome |
| Title | The Importance of Bacterial Superantigens Produced by Staphylococcus aureus in the Treatment of Atopic Dermatitis Using Povidone-Iodine |
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