Impact of non-genetic factors on severe cutaneous adverse reactions and associated mortality in ESRD patients: Advancing clinical guidance

• Published in: The American journal of the medical sciences Vol. 369; no. 5; p. 613
• Main Authors: Smaha, Katlyn M, Talebi, Nadia N, Waller, Jennifer L, Baer, Stephanie L, Bollag, Wendy B
• Format: Journal Article
• Language: English
• Published: United States 01.05.2025
• Subjects: Adult; Aged; Drug Hypersensitivity Syndrome - etiology; Drug Hypersensitivity Syndrome - mortality; Female; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Male; Middle Aged; Retrospective Studies; Risk Factors; Stevens-Johnson Syndrome - epidemiology; Stevens-Johnson Syndrome - etiology; Stevens-Johnson Syndrome - mortality; United States - epidemiology; United States; Stevens-Johnson syndrome (SJS); End-stage renal disease (ESRD); Drug reaction with eosinophilia and systemic symptoms (DRESS); Toxic epidermal necrolysis (TEN); Severe cutaneous adverse reaction (SCAR)

In end-stage renal disease (ESRD), reduced renal function affects medication response and clearance, increasing risk of adverse drug reactions. Renal disease is a risk factor for poor prognosis in severe cutaneous adverse reactions (SCARs). The effects of SCARs in ESRD patients are less understood....