Metformin is Protective Against the Development of Mood Disorders

• Published in: Pharmacopsychiatry Vol. 56; no. 1; pp. 25 - 31
• Main Authors: Lake, Jacqueline, Bortolasci, Chiara C., Stuart, Amanda L., Pasco, Julie A., Kidnapillai, Srisaiyini, Spolding, Briana, Truong, Trang T. T., Panizzutti, Bruna, Liu, Zoe S. J., Dean, Olivia M., Crowley, Tamsyn, Richardson, Mark, Kim, Jee Hyun, Berk, Michael, Williams, Lana J., Walder, Ken
• Format: Journal Article
• Language: English
• Published: Rüdigerstraße 14, 70469 Stuttgart, Germany Georg Thieme Verlag KG 01.01.2023
• Subjects: Diabetes Mellitus, Type 2 - drug therapy; Humans; Metformin - pharmacology; Metformin - therapeutic use; Mood Disorders - drug therapy; Original Paper; Retrospective Studies; metformin; mood disorder; drug repurposing; gene expression signature; pharmacoepidemiology

Abstract Introduction Mood disorders are a major cause of disability, and current treatment options are inadequate for reducing the burden on a global scale. The aim of this project was to identify drugs suitable for repurposing to treat mood disorders. Methods This mixed-method study utilized gene...