Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease

• Published in: Life sciences (1973) Vol. 73; no. 14; pp. 1795 - 1803
• Main Authors: Colurso, Gloria J, Nilson, James E, Vervoort, Lucia G
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 22.08.2003
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Apoptosis; Beta-amyloid; Cell Count; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; DNA Fragmentation; Frontal Lobe - metabolism; Frontal Lobe - pathology; Humans; In Situ Nick-End Labeling; Insular cortex; Midfrontal gyrus; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Pyramidal Cells - cytology; Pyramidal Cells - pathology; Alzheimer's disease; Insular cortex; Beta-amyloid; Midfrontal gyrus; Apoptosis

It has been suggested that the neurodegeneration that occurs with Alzheimer's disease (AD) may result from apoptosis, a process of programmed cell death. Neuronal injury, induced by abnormal aggregates of beta-amyloid peptide, has been identified as an apoptotic trigger. In the present study, b...