Insomnia in patients with MRI-negative epilepsy: The associated factors and 3D-pCASL cerebral blood flow perfusion changes

• Published in: Epilepsy & behavior Vol. 158; p. 109903
• Main Authors: Tan, Bofei, Xu, Xianrui, Liu, Qiang, Chen, Rong, Chen, Qiuyan, Qin, Yameng, Li, Mengyun, Wang, Xu, Yang, Ping, Jin, Yanzi, Jia, Xiaodan, Zhang, Qing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2024
• Subjects: 3D-pCASL; Adult; Brain - blood supply; Brain - diagnostic imaging; Brain - physiopathology; Cerebrovascular Circulation - physiology; Epilepsy - complications; Epilepsy - diagnostic imaging; Epilepsy - physiopathology; Female; Humans; Imaging, Three-Dimensional; Insomnia; Left amygdala; Magnetic Resonance Imaging; Male; Middle Aged; MRI-negative epilepsy; Nocturnal seizures; Retrospective Studies; Sleep Initiation and Maintenance Disorders - diagnostic imaging; Sleep Initiation and Maintenance Disorders - physiopathology; Spin Labels; Young Adult; MRI-negative epilepsy; Left amygdala; 3D-pCASL; Insomnia; Nocturnal seizures
• ISSN: 1525-5050; 1525-5069; 1525-5069
• DOI: 10.1016/j.yebeh.2024.109903

•The prevalence of insomnia in MRI-negative epilepsy is 19.2%.•In addition to anxiety and EDS, nocturnal seizures were also significantly associated with insomnia in MRI-negative epilepsy.•The significant reduction of CBF values in left amygdala may be related to the underlying pathological mechanism of insomnia in epilepsy. This study aimed to identify the factors associated with insomnia in MRI-negative epilepsy and uncover the underlying pathological mechanism driving insomnia within the context of epilepsy. We conducted a retrospective study of patients with MRI-negative epilepsy recruited consecutively from December 2021 to December 2022. All subjects completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Additionally, some subjects underwent the three-dimensional pseudo continuous arterial spin labeling(3D-pCASL) imaging examination. Bilateral frontal lobe, temporal lobe, hippocampus, thalamus, amygdala, caudate nucleus and lenticular nucleus were selected as regions of interest(ROI) and cerebral blood flow(CBF) values were measured in these regions. Subjects were classified into insomnia (ISI ≥ 10) or non-insomnia (ISI < 10) groups, and univariate and stepwise logistic regression analyses were employed to identify the factors associated with insomnia. Furthermore, CBF values in each ROI were compared between the two groups to identify the brain regions potentially related to the underlying pathological mechanism of insomnia in epilepsy. A total of 73 patients with MRI-negative epilepsy were recruited in this study(men, 49.3 %). Among them, 14 patients(19.2 %) had insomnia. Univariate regression revealed that nocturnal seizures, number of anti-seizure medication(ASM), anxiety, use of valproic acid(VPA), depression, and excessive daytime sleepiness(EDS) may be associated with insomnia in MRI-negative epilepsy (all p＜0.05). Stepwise regression demonstrated that nocturnal seizures, anxiety, and EDS were independently associated with insomnia in MRI-negative epilepsy (OR[95 %CI]P: 14.64[2.02–106.27]0.008,49.35[3.06–796.61]0.006, 13.28[1.25–140.66]0.032, respectively). Furthermore, CBF values in the left amygdala were significantly lower in patients with MRI- negative epilepsy who had insomnia. The prevalence of insomnia in MRI-negative epilepsy is 19.2%. Nocturnal seizures, anxiety, and EDS were independently associated with insomnia in MRI-negative epilepsy. The noteworthy decrease in CBF values in the left amygdala might be connected to the underlying pathological mechanism of insomnia in epilepsy.