An anchor-tether ‘hindered’ HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model

• Published in: British journal of anaesthesia : BJA Vol. 131; no. 4; pp. 745 - 763
• Main Authors: Tibbs, Gareth R., Uprety, Rajendra, Warren, J. David, Beyer, Nicole P., Joyce, Rebecca L., Ferrer, Matthew A., Mellado, Wilfredo, Wong, Victor S.C., Goldberg, David C., Cohen, Melanie W., Costa, Christopher J., Li, Zhucui, Zhang, Guoan, Dephoure, Noah E., Barman, Dipti N., Sun, Delin, Ingólfsson, Helgi I., Sauve, Anthony A., Willis, Dianna E., Goldstein, Peter A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2023; Elsevier
• Subjects: Animals; antihyperalgesia; Drug Inverse Agonism; Electrophysiological Phenomena; HCN1; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - therapeutic use; ion channel; nerve injury; Neuralgia - drug therapy; neuropathic pain; Pain; Quality of Life; rat; Rats; neuropathic pain; rat; ion channel; nerve injury; antihyperalgesia; HCN1

Neuropathic pain impairs quality of life, is widely prevalent, and incurs significant costs. Current pharmacological therapies have poor/no efficacy and significant adverse effects; safe and effective alternatives are needed. Hyperpolarisation-activated cyclic nucleotide-regulated (HCN) channels are...