The remodeling of glycoconjugates in mice
A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various glycoconjugates in vivo, gene targeting approaches have been applied to glycosyltransferase and glycosidase enzymes involved in different biosynt...
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| Published in | Biochimica et biophysica acta Vol. 1473; no. 1; pp. 123 - 136 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
06.12.1999
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| Abstract | A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various glycoconjugates in vivo, gene targeting approaches have been applied to glycosyltransferase and glycosidase enzymes involved in different biosynthetic pathways. The growing number of gene targeted mice generated have brought confirmations of the importance of both core and terminal glycosylation enzymes in normal development and physiology. Of particular interest has been the degree of cell and tissue specificity of phenotypes generated by systemic null mutations as well as the number of enzymes belonging to multigene families having overlapping activities. |
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| AbstractList | A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various glycoconjugates in vivo, gene targeting approaches have been applied to glycosyltransferase and glycosidase enzymes involved in different biosynthetic pathways. The growing number of gene targeted mice generated have brought confirmations of the importance of both core and terminal glycosylation enzymes in normal development and physiology. Of particular interest has been the degree of cell and tissue specificity of phenotypes generated by systemic null mutations as well as the number of enzymes belonging to multigene families having overlapping activities.A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various glycoconjugates in vivo, gene targeting approaches have been applied to glycosyltransferase and glycosidase enzymes involved in different biosynthetic pathways. The growing number of gene targeted mice generated have brought confirmations of the importance of both core and terminal glycosylation enzymes in normal development and physiology. Of particular interest has been the degree of cell and tissue specificity of phenotypes generated by systemic null mutations as well as the number of enzymes belonging to multigene families having overlapping activities. A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various glycoconjugates in vivo, gene targeting approaches have been applied to glycosyltransferase and glycosidase enzymes involved in different biosynthetic pathways. The growing number of gene targeted mice generated have brought confirmations of the importance of both core and terminal glycosylation enzymes in normal development and physiology. Of particular interest has been the degree of cell and tissue specificity of phenotypes generated by systemic null mutations as well as the number of enzymes belonging to multigene families having overlapping activities. |
| Author | Hennet, Thierry Ellies, Lesley G. |
| Author_xml | – sequence: 1 givenname: Thierry surname: Hennet fullname: Hennet, Thierry email: thennet@access.unizh.ch organization: Institute of Physiology, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland – sequence: 2 givenname: Lesley G. surname: Ellies fullname: Ellies, Lesley G. organization: Division of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10580133$$D View this record in MEDLINE/PubMed |
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| Keywords | Gene targeting Mouse Cre- loxP recombination Glycosyltransferase |
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| Snippet | A role for glycoconjugates in mediating cellular interactions is well established. To further understand the formation, function and regulation of various... |
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| SubjectTerms | Animals Cre- loxP recombination Gene Targeting Glycoconjugates - biosynthesis Glycoconjugates - metabolism Glycoside Hydrolases - genetics Glycoside Hydrolases - metabolism Glycosylation Glycosyltransferase Glycosyltransferases - genetics Glycosyltransferases - metabolism Integrases - metabolism Mice Mice, Transgenic Mouse Phenotype Recombination, Genetic Viral Proteins |
| Title | The remodeling of glycoconjugates in mice |
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