Adrenomedullin receptors: molecular identity and function

• Published in: Peptides (New York, N.Y. : 1980) Vol. 22; no. 11; pp. 1753 - 1763
• Main Authors: Hay, Debbie L, Smith, David M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2001
• Subjects: Adrenomedullin; Adrenomedullin receptors; Animals; Calcitonin Gene-Related Peptide - metabolism; Calcitonin Receptor-Like Protein; CGRP receptors; CRLR; Endocytosis; Forecasting; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins - metabolism; Peptides - metabolism; RAMPs; Receptor Activity-Modifying Proteins; Receptors, Adrenomedullin; Receptors, Calcitonin - metabolism; Receptors, Calcitonin - physiology; Receptors, Peptide - metabolism; Receptors, Peptide - physiology; Adrenomedullin receptors; CRLR; RAMPs; CGRP receptors

Since its discovery in 1993 adrenomedullin (AM) has been the subject over 600 published articles. This multifunctional peptide has powerful vasodilator actions and recent evidence from AM gene-deleted mice suggest that AM plays an essential role in vascular development. However the lack of valid AM...