Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders

• Published in: Swiss medical weekly Vol. 144; no. 708; p. w13917
• Main Authors: Moll, Lorna, El-Ami, Tayir, Cohen, Ehud
• Format: Journal Article
• Language: English
• Published: Switzerland SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 13.02.2014
• Subjects: aging; Aging - metabolism; Animals; Brain - metabolism; Homeostasis; Humans; Insulin - metabolism; Insulin-Like Growth Factor I - antagonists & inhibitors; Insulin-Like Growth Factor I - metabolism; insulin/IGF signalling; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - therapy; neurodegenerative disorders; proteostasis; proteotoxicity; Signal Transduction - genetics; Signal Transduction - physiology

Aging is the major risk factor for the development of human neurodegenerative maladies such as Alzheimer's, Huntington's and Parkinson's diseases, and prion disorders, all of which stem from toxic protein aggregation. Although sporadic cases typically onset during the patient's s...