Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration

• Published in: Biochimica et biophysica acta Vol. 1800; no. 6; pp. 580 - 590
• Main Authors: Fortenberry, Yolanda M., Brandal, Stephanie, Bialas, Ryan C., Church, Frank C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2010
• Subjects: Base Sequence; Breast cancer cells; Breast Neoplasms - enzymology; Breast Neoplasms - pathology; Cathepsin L - metabolism; Cathepsins; Cell Line, Tumor; Cell migration; DNA Primers; Fluorescent Antibody Technique; Heparin; Humans; Mutagenesis, Site-Directed; Neoplasm Metastasis; Protein C inhibitor; Protein C Inhibitor - pharmacology; Serpins; siRNA; AT; DTT; SI; Protein C inhibitor; PCI; Cathepsins; RCL; siRNA; Heparin; Breast cancer cells; Cell migration; serpins

Protein C inhibitor (PCI) is a plasma serine protease inhibitor (serpin) that regulates several serine proteases in coagulation including thrombin and activated protein C. However, the physiological role of PCI remains under investigation. The cysteine protease, cathepsin L, has a role in many physi...