Characterization of Naturally Occurring and Lamivudine-Induced Surface Gene Mutants of Hepatitis B Virus in Patients with Chronic Hepatitis B in India

• Published in: Intervirology Vol. 49; no. 3; pp. 152 - 160
• Main Authors: Kazim, Syed Naqui, Sarin, Shiv Kumar, Sharma, Barjesh Chander, Khan, Luqman Ahmad, Hasnain, Seyed Ehtesham
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2006
• Subjects: Adult; Amino Acid Sequence; Antiviral Agents - therapeutic use; Drug Resistance, Viral - genetics; Female; Genes, Viral - drug effects; Hepatitis B; Hepatitis B Surface Antigens - genetics; Hepatitis B virus; Hepatitis B virus - drug effects; Hepatitis B virus - genetics; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - virology; Humans; India; Lamivudine - therapeutic use; Male; Middle Aged; Molecular Sequence Data; Mutation; Original Paper; Sequence Alignment; Sequence Analysis, Protein; Treatment Outcome; Viral Load; India; Mutations; Lamivudine; Antiviral therapy; Resistance, lamivudine; Hepatitis B virus

Background: Besides vaccine escape or immune escape hepatitis B virus (HBV) mutants, naturally occurring and drug-induced mutations have been reported in the surface gene (S-gene) of HBV. Aim: To investigate the frequency and profile of naturally occurring S-gene mutants and the influence of long-te...