A pivotal role for glycans at the interface between Trichinella spiralis and its host

The nematode Trichinella spiralis demonstrates a simple but novel parasitic life-cycle, completing all of its development in intracellular habitats. This feature of the life-cycle has challenged investigators aiming to elucidate mechanisms of parasitism. Investigations of immunity showed a dominant...

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Bibliographic Details
Published inVeterinary parasitology Vol. 101; no. 3; pp. 249 - 260
Main Authors Appleton, J.A., Romaris, F.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 22.11.2001
Subjects
Animals
Antibodies, Helminth - biosynthesis
Glycans
Histocytochemistry
Host-Parasite Interactions - physiology
Humans
Immunity
Immunity, Cellular
Immunodominant Epitopes - immunology
Intestines - immunology
Intestines - parasitology
Larva
Life Cycle Stages
Muscle, Skeletal - chemistry
Muscle, Skeletal - parasitology
Polysaccharides - immunology
Polysaccharides - physiology
Rapid expulsion
Trichinella spiralis
Trichinella spiralis - immunology
Trichinella spiralis - physiology
Trichinellosis - immunology
Trichinellosis - parasitology
Trichinellosis - veterinary
Trichinella spiralis
Glycans
Immunity
Rapid expulsion
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Summary:The nematode Trichinella spiralis demonstrates a simple but novel parasitic life-cycle, completing all of its development in intracellular habitats. This feature of the life-cycle has challenged investigators aiming to elucidate mechanisms of parasitism. Investigations of immunity showed a dominant influence of N-glycans in the responses to larval T. spiralis. It has become evident that novel glycans are positioned to play important roles in parasitism, as well as immunity, in infection with this nematode.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(01)00570-2