Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia

Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with...

Full description

Saved in:
Bibliographic Details
Published inEuropean neuropsychopharmacology Vol. 12; no. 2; pp. 145 - 152
Main Authors Braus, Dieter F, Ende, Gabriele, Weber-Fahr, Wolfgang, Demirakca, Traute, Tost, Heike, Henn, Fritz A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2002
Subjects
Adult
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Cell Survival - drug effects
Cell Survival - physiology
Chronic Disease
Cingulate gyrus
Cross-Sectional Studies
Female
Gyrus Cinguli - cytology
Gyrus Cinguli - drug effects
Gyrus Cinguli - metabolism
Humans
Magnetic Resonance Spectroscopy - statistics & numerical data
Male
Neuronal viability
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - metabolism
Schizophrenia - pathology
Spectroscopic imaging
WCST
Schizophrenia
Neuronal viability
Neuropsychology
Spectroscopic imaging
WCST
Cingulate gyrus
Online AccessGet full text

Cover

Abstract Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with typical neuroleptics, the other with atypical medications. 1H MR-spectroscopic imaging of the anterior cingulate gyrus was performed in all patients. Perseveration errors in the Wisconsin Card Sorting Test (WCST) served as an additional marker for cingulate gyrus function. Our results showed that N-acetylaspartate (NAA), a measure of neuronal function, was closely correlated with perseveration errors seen on the WCST. Patients treated with atypical medications had fewer errors on the WCST and higher NAA levels than those on typical medications, and there was a correlation between the time treated with atypical medication, higher NAA levels and better test performance. These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner.
AbstractList Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with typical neuroleptics, the other with atypical medications. 1H MR-spectroscopic imaging of the anterior cingulate gyrus was performed in all patients. Perseveration errors in the Wisconsin Card Sorting Test (WCST) served as an additional marker for cingulate gyrus function. Our results showed that N-acetylaspartate (NAA), a measure of neuronal function, was closely correlated with perseveration errors seen on the WCST. Patients treated with atypical medications had fewer errors on the WCST and higher NAA levels than those on typical medications, and there was a correlation between the time treated with atypical medication, higher NAA levels and better test performance. These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner.
Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical antipsychotic medication leading to improvement in cognitive function. We studied two groups of schizophrenic patients, one treated exclusively with typical neuroleptics, the other with atypical medications. 1H MR-spectroscopic imaging of the anterior cingulate gyrus was performed in all patients. Perseveration errors in the Wisconsin Card Sorting Test (WCST) served as an additional marker for cingulate gyrus function. Our results showed that N-acetylaspartate (NAA), a measure of neuronal function, was closely correlated with perseveration errors seen on the WCST. Patients treated with atypical medications had fewer errors on the WCST and higher NAA levels than those on typical medications, and there was a correlation between the time treated with atypical medication, higher NAA levels and better test performance. These results suggest that atypical antipsychotics modify the function of anterior cingulate neurons in a specific manner.
Author Tost, Heike
Weber-Fahr, Wolfgang
Braus, Dieter F
Henn, Fritz A
Ende, Gabriele
Demirakca, Traute
Author_xml – sequence: 1
  givenname: Dieter F
  surname: Braus
  fullname: Braus, Dieter F
  email: dfbraus@zi-mannheim.de
– sequence: 2
  givenname: Gabriele
  surname: Ende
  fullname: Ende, Gabriele
– sequence: 3
  givenname: Wolfgang
  surname: Weber-Fahr
  fullname: Weber-Fahr, Wolfgang
– sequence: 4
  givenname: Traute
  surname: Demirakca
  fullname: Demirakca, Traute
– sequence: 5
  givenname: Heike
  surname: Tost
  fullname: Tost, Heike
– sequence: 6
  givenname: Fritz A
  surname: Henn
  fullname: Henn, Fritz A
BackLink https://www.ncbi.nlm.nih.gov/pubmed/11872332$$D View this record in MEDLINE/PubMed
BookMark eNqFkctqHDEQRUWwicdOPiFBq-As2tZjpqXOxhgTP8DBkAdkJzTV1W6FHqktqW3Gf5K_jcYzJMtoU6A6t4pb95Ds-eCRkHecnXDG69NvrBHzqlHq5zETH1l5shKvyIxrJSula7FHZn-RA3KY0i_G-ELK5jU54IUSUooZ-X05ecgueOfvqfUt9TjF4O1AH51dusHlNQ0dzT2WbsboQqRQ2GmwGXdwol0YhvC0HZHdmNbQh-yA5og2r9DnT_TL1yqNCDmGBGEsPbey9xuF8xT6MqV8Jejdcxj7iN7ZN2S_s0PCt7t6RH5cfv5-cV3d3l3dXJzfViBrnisQYKVVsGgQWgUaxVyImos51o2U2jLb1krYblk3rOVac6U7BrXic21tq5byiHzYzh1jeJgwZbNyCXAYrMcwJVPIpuF6UcDFFoTiIUXszBiLibg2nJlNJuYlE7M5uGHCvGRiRNG93y2Ylits_6l2IRTgbAtgsfnoMJoEDj1g62K5mGmD-8-KP19Kotk
CitedBy_id crossref_primary_10_1002_nbm_1080
crossref_primary_10_1016_j_biopsych_2010_10_004
crossref_primary_10_1007_s00406_013_0451_y
crossref_primary_10_1007_s00406_008_0810_2
crossref_primary_10_1016_j_pscychresns_2010_02_008
crossref_primary_10_1016_j_pscychresns_2012_02_003
crossref_primary_10_1016_S0920_9964_02_00528_5
crossref_primary_10_1016_j_pscychresns_2014_04_010
crossref_primary_10_1038_sj_npp_1300850
crossref_primary_10_1016_j_bbr_2009_01_026
crossref_primary_10_1016_j_jpsychires_2007_06_006
crossref_primary_10_1093_brain_awh632
crossref_primary_10_1016_j_neuroimage_2014_03_009
crossref_primary_10_1038_sj_npp_1300603
crossref_primary_10_1016_j_jpsychires_2011_02_004
crossref_primary_10_1016_j_schres_2004_10_010
crossref_primary_10_1007_s00406_005_0562_1
crossref_primary_10_3390_ijms161024475
crossref_primary_10_1016_j_schres_2020_11_063
crossref_primary_10_1016_j_neuroimage_2006_04_189
crossref_primary_10_3109_15622975_2011_566354
crossref_primary_10_1111_j_1440_1819_2006_01515_x
crossref_primary_10_1038_s41598_021_84954_8
crossref_primary_10_1016_j_schres_2007_05_024
crossref_primary_10_1038_sj_npp_1301293
crossref_primary_10_1038_srep09109
crossref_primary_10_1038_tp_2015_26
crossref_primary_10_1097_RMR_0b013e318181e0be
crossref_primary_10_1007_s00115_003_1593_3
crossref_primary_10_1007_s00115_004_1713_8
crossref_primary_10_1038_sj_npp_1301631
crossref_primary_10_1080_08964289_2010_540262
crossref_primary_10_2147_nedt_2007_3_1_87
crossref_primary_10_1007_s00117_004_1161_2
crossref_primary_10_1016_j_pscychresns_2009_04_007
crossref_primary_10_1016_j_cogsys_2022_10_008
crossref_primary_10_1016_j_schres_2011_07_011
crossref_primary_10_1080_09540260701486332
crossref_primary_10_1016_j_brainres_2010_04_083
crossref_primary_10_1016_j_brainresrev_2003_11_001
crossref_primary_10_1038_npp_2016_247
crossref_primary_10_1016_j_schres_2012_02_031
crossref_primary_10_31887_DCNS_2009_11_3_jhunsberger
crossref_primary_10_3390_ijms161024387
crossref_primary_10_1007_s00117_004_1156_z
crossref_primary_10_1016_j_neuroimage_2005_08_013
crossref_primary_10_3906_sag_1502_9
crossref_primary_10_1111_jnc_12398
ContentType Journal Article
Copyright 2002
Copyright_xml – notice: 2002
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/S0924-977X(02)00003-2
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1873-7862
EndPage 152
ExternalDocumentID 10_1016_S0924_977X_02_00003_2
11872332
S0924977X02000032
Genre Research Support, Non-U.S. Gov't
Journal Article
Comparative Study
GroupedDBID ---
--K
--M
.1-
.FO
.~1
0R~
1B1
1P~
1RT
1~.
1~5
29G
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
9JO
AABNK
AACTN
AADFP
AADPK
AAEDT
AAEDW
AAGJA
AAGUQ
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATCM
AAXLA
AAXUO
ABBQC
ABCQJ
ABFNM
ABFRF
ABIVO
ABJNI
ABLVK
ABMAC
ABMZM
ABOYX
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACGFS
ACIUM
ACRLP
ACXNI
ADBBV
ADEZE
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AEVXI
AFCTW
AFKWA
AFRHN
AFTJW
AFXIZ
AFYLN
AGHFR
AGUBO
AGWIK
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
AJUYK
AKRLJ
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HDW
HMK
HMO
HMQ
HMT
HVGLF
HZ~
IHE
J1W
KOM
LCYCR
LX8
M29
M2V
M34
M41
MO0
MOBAO
N9A
O-L
O9-
OAUVE
OGGZJ
OH0
OKEIE
OU-
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SEL
SES
SEW
SNS
SPCBC
SPT
SSB
SSH
SSN
SSP
SSY
SSZ
T5K
UNMZH
WUQ
XPP
Z5R
~G-
AAXKI
AFJKZ
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c361t-c2ca3a7c59ecd7c8e24226124e69338a0ad672afb690d188178f0c67148aad7b3
IEDL.DBID AIKHN
ISSN 0924-977X
IngestDate Fri Oct 25 09:45:14 EDT 2024
Thu Sep 26 17:06:16 EDT 2024
Sat Sep 28 07:37:05 EDT 2024
Fri Feb 23 02:26:55 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Schizophrenia
Neuronal viability
Neuropsychology
Spectroscopic imaging
WCST
Cingulate gyrus
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c361t-c2ca3a7c59ecd7c8e24226124e69338a0ad672afb690d188178f0c67148aad7b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 11872332
PQID 71499185
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_71499185
crossref_primary_10_1016_S0924_977X_02_00003_2
pubmed_primary_11872332
elsevier_sciencedirect_doi_10_1016_S0924_977X_02_00003_2
PublicationCentury 2000
PublicationDate 2002-04-01
PublicationDateYYYYMMDD 2002-04-01
PublicationDate_xml – month: 04
  year: 2002
  text: 2002-04-01
  day: 01
PublicationDecade 2000
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle European neuropsychopharmacology
PublicationTitleAlternate Eur Neuropsychopharmacol
PublicationYear 2002
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Kapur, Zipursky, Remington (BIB35) 1999; 156
Olney, Farber (BIB45) 1995; 52
Weiser, Shneider-Beeri, Nakash, Brill, Bawnik, Reiss, Hocherman, Davidson (BIB55) 2000; 46
Deutch, Duman (BIB21) 1996; 70
Ingvar, Philipson (BIB33) 1977; 2
De Stefano, Matthews, Arnold (BIB18) 1995; 34
Bleuler (BIB7) 1950
Young, Soher, Maudsley (BIB58) 1998; 40
Weinberger, Berman, Zec (BIB54) 1986; 43
Soher, Young, Govindaraju, Maudsley (BIB51) 1998; 40
Young, Govindaraju, Soher, Maudsley (BIB57) 1998; 40
Carter, Perlstein, Ganguli, Brar, Mintun, Cohen (BIB12) 1998; 155
Corson, Nopoulos, Miller, Arndt, Andreasen (BIB14) 1999; 156
Miller, Andreasen, O’Leary, Watkins, Boles Ponto, Hichwa (BIB41) 2001; 49
Nagahama, Fukuyama, Yamauchi, Matsuzaki, Konishi, Shibasaki, Kimura (BIB43) 1996; 119
Deicken, Zhou, Schuff, Weiner (BIB20) 1997; 27
Meltzer, Lee, Ranjan (BIB39) 1994; 384
Perry, Braff (BIB48) 1998; 33
Michaelis, Merboldt, Bruhn, Hanicke, Frahm (BIB40) 1993; 187
Wolkin, Jaeger, Brodie, Wolf, Fowler, Rotrosen, Gomez-Mont, Cancro (BIB56) 1985; 142
Ende, Braus, Walter, Weber-Fahr, Soher, Maudsley, Henn (BIB22) 2000; 41
Fletcher (BIB24) 1998; 1
Maudsley, Matson, Hugg, Weiner (BIB38) 1994; 31
Butler, Jenkins, Sprock, Braff (BIB8) 1992; 7
Cuesta, Peralta, Zarzuela (BIB16) 2001; 48
Catafau, Parellada, Lomena, Bernardo, Setoain, Catarineu, Pavia, Herranz (BIB13) 1998; 83
Bertolino, Callicott, Nawroz, Mattay, Duyn, Tedeschi, Frank, Weinberger (BIB4) 1998; 18
Liddle (BIB37) 1987; 17
Benes, McSparren, Bird, SanGiovanni, Vincent (BIB1) 1991; 48
Davie, Silver, Barker, Tofts, Thompson, McDonald, Miller (BIB17) 1999; 67
Harrison (BIB28) 1999; 40
Honey, Bullmore, Soni, Varatheesan, Williams, Sharma (BIB31) 1999; 96
Carlsson, Hansson, Waters, Carlsson (BIB10) 1997; 61
Green (BIB27) 1998
Bertolino, Knable, Saunders, Callicott, Kolachana, Mattay, Bachevalier, Frank, Egan, Weinberger (BIB6) 1999; 45
Weinberger (BIB53) 1997; 58
Oie, Rund (BIB44) 1999; 156
Bertolino, Esposito, Callicott, Mattay, Van Horn, Frank, Berman, Weinberger (BIB5) 2000; 157
Crider (BIB15) 1997; 23
Robertson, Fibiger (BIB49) 1992; 46
Berman, Ostrem, Randolph, Gold, Goldberg, Coppola, Carson, Herscovitch, Weinberger (BIB2) 1995; 33
Pardo, Fox, Raichle (BIB46) 1991; 349
Harvey, Keefe (BIB29) 2001; 158
Haznedar, Buchsbaum, Luu, Hazlett, Siegel, Lohr, Wu, Haier, Bunney (BIB30) 1997; 154
Jentsch, Redmond, Elsworth, Taylor, Youngren, Roth (BIB34) 1997; 277
Paulman, Devous, Gregory, Herman, Jennings, Bonte, Nasrallah, Raese (BIB47) 1990; 27
Ichikawa, Meltzer (BIB32) 1999; 249
King (BIB36) 1990; 157
Ende, Laxer, Knowlton, Matson, Schuff, Fein, Weiner (BIB23) 1997; 202
Szeszko, Bilder, Lencz, Ashtari, Goldman, Reiter, Wu, Lieberman (BIB52) 2000; 43
Goldstein, Goodman, Seidman, Kennedy, Makris, Lee, Tourville, Caviness, Faraone, Tsuang (BIB26) 1999; 56
Robertson, Matsumura, Fibiger (BIB50) 1994; 271
Carter, Mintun, Nichols, Cohen (BIB11) 1997; 154
Murray, O’Callaghan, Castle, Lewis (BIB42) 1992; 18
Bertolino, Callicott, Mattay, Weidenhammer, Rakow, Egan, Weinberger (BIB3) 2001; 49
Bymaster, Calligaro, Falcone, Marsh, Moore, Tye, Seeman, Wong (BIB9) 1996; 14
Deicken, Merrin, Floyd, Weiner (BIB19) 1995; 14
Goldberg, Weinberger (BIB25) 1996; 57
References_xml – volume: 33
  start-page: 1027
  year: 1995
  end-page: 1046
  ident: BIB2
  article-title: Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: a positron emission tomography study
  publication-title: Neuropsychologia
  contributor:
    fullname: Weinberger
– volume: 83
  start-page: 67
  year: 1998
  end-page: 74
  ident: BIB13
  article-title: Role of the cingulate gyrus during the Wisconsin Card Sorting Test: a single photon emission computed tomography study in normal volunteers
  publication-title: Psychiatry Res.
  contributor:
    fullname: Herranz
– volume: 49
  start-page: 704
  year: 2001
  end-page: 715
  ident: BIB41
  article-title: Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia
  publication-title: Biol. Psychiatry
  contributor:
    fullname: Hichwa
– volume: 271
  start-page: 1058
  year: 1994
  end-page: 1066
  ident: BIB50
  article-title: Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Fibiger
– volume: 155
  start-page: 1285
  year: 1998
  end-page: 1287
  ident: BIB12
  article-title: Functional hypofrontality and working memory dysfunction in schizophrenia
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Cohen
– volume: 40
  start-page: 822
  year: 1998
  end-page: 831
  ident: BIB51
  article-title: Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: Maudsley
– volume: 61
  start-page: 75
  year: 1997
  end-page: 94
  ident: BIB10
  article-title: Neurotransmitter aberrations in schizophrenia: new perspectives and therapeutic implications
  publication-title: Life Sci.
  contributor:
    fullname: Carlsson
– volume: 156
  start-page: 1200
  year: 1999
  end-page: 1204
  ident: BIB14
  article-title: Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Andreasen
– volume: 2
  start-page: 230
  year: 1977
  end-page: 237
  ident: BIB33
  article-title: Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance
  publication-title: Ann. Neurol.
  contributor:
    fullname: Philipson
– volume: 52
  start-page: 998
  year: 1995
  end-page: 1007
  ident: BIB45
  article-title: Glutamate receptor dysfunction and schizophrenia
  publication-title: Arch. Gen. Psychiatry
  contributor:
    fullname: Farber
– volume: 249
  start-page: 90
  year: 1999
  end-page: 98
  ident: BIB32
  article-title: Relationship between dopaminergic and serotonergic neuronal activity in the frontal cortex and the action of typical and atypical antipsychotic drugs
  publication-title: Eur. Arch. Psychiatry Clin. Neurosci.
  contributor:
    fullname: Meltzer
– volume: 154
  start-page: 682
  year: 1997
  end-page: 684
  ident: BIB30
  article-title: Decreased anterior cingulate gyrus metabolic rate in schizophrenia
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Bunney
– volume: 349
  start-page: 61
  year: 1991
  end-page: 64
  ident: BIB46
  article-title: Localization of a human system for sustained attention by positron emission tomography
  publication-title: Nature
  contributor:
    fullname: Raichle
– volume: 31
  start-page: 645
  year: 1994
  end-page: 651
  ident: BIB38
  article-title: Reduced phase encoding in spectroscopic imaging
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: Weiner
– volume: 43
  start-page: 114
  year: 1986
  end-page: 124
  ident: BIB54
  article-title: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence
  publication-title: Arch. Gen. Psychiatry
  contributor:
    fullname: Zec
– volume: 14
  start-page: 177
  year: 1995
  end-page: 181
  ident: BIB19
  article-title: Correlation between left frontal phospholipids and Wisconsin Card Sort Test performance in schizophrenia
  publication-title: Schizophr. Res
  contributor:
    fullname: Weiner
– volume: 58
  start-page: 22
  year: 1997
  end-page: 27
  ident: BIB53
  article-title: The biological basis of schizophrenia: new directions
  publication-title: J. Clin. Psychiatry
  contributor:
    fullname: Weinberger
– volume: 156
  start-page: 1216
  year: 1999
  end-page: 1222
  ident: BIB44
  article-title: Neuropsychological deficits in adolescent-onset schizophrenia compared with attention deficit hyperactivity disorder
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Rund
– volume: 48
  start-page: 996
  year: 1991
  end-page: 1001
  ident: BIB1
  article-title: Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients
  publication-title: Arch. Gen. Psychiatry
  contributor:
    fullname: Vincent
– year: 1950
  ident: BIB7
  publication-title: Dementia Praecox or the Group of Schizophrenias
  contributor:
    fullname: Bleuler
– volume: 33
  start-page: 69
  year: 1998
  end-page: 77
  ident: BIB48
  article-title: A multimethod approach to assessing perseverations in schizophrenia patients
  publication-title: Schizophr. Res.
  contributor:
    fullname: Braff
– volume: 96
  start-page: 13432
  year: 1999
  end-page: 13437
  ident: BIB31
  article-title: Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Sharma
– volume: 154
  start-page: 1670
  year: 1997
  end-page: 1675
  ident: BIB11
  article-title: Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Cohen
– volume: 40
  start-page: 812
  year: 1998
  end-page: 815
  ident: BIB57
  article-title: Automated spectral analysis I: formation of a priori information by spectral simulation
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: Maudsley
– volume: 157
  start-page: 26
  year: 2000
  end-page: 33
  ident: BIB5
  article-title: Specific relationship between prefrontal neuronal
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Weinberger
– volume: 56
  start-page: 537
  year: 1999
  end-page: 547
  ident: BIB26
  article-title: Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging
  publication-title: Arch. Gen. Psychiatry
  contributor:
    fullname: Tsuang
– volume: 48
  start-page: 17
  year: 2001
  end-page: 28
  ident: BIB16
  article-title: Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study
  publication-title: Schizophr. Res.
  contributor:
    fullname: Zarzuela
– volume: 49
  start-page: 39
  year: 2001
  end-page: 46
  ident: BIB3
  article-title: The effect of treatment with antipsychotic drugs on brain
  publication-title: Biol. Psychiatry
  contributor:
    fullname: Weinberger
– volume: 18
  start-page: 319
  year: 1992
  end-page: 332
  ident: BIB42
  article-title: A neurodevelopmental approach to the classification of schizophrenia
  publication-title: Schizophr. Bull.
  contributor:
    fullname: Lewis
– volume: 70
  start-page: 377
  year: 1996
  end-page: 389
  ident: BIB21
  article-title: The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization
  publication-title: Neuroscience
  contributor:
    fullname: Duman
– volume: 142
  start-page: 564
  year: 1985
  end-page: 571
  ident: BIB56
  article-title: Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Cancro
– volume: 23
  start-page: 63
  year: 1997
  end-page: 74
  ident: BIB15
  article-title: Perseveration in schizophrenia
  publication-title: Schizophr. Bull.
  contributor:
    fullname: Crider
– volume: 1
  start-page: 266
  year: 1998
  end-page: 267
  ident: BIB24
  article-title: The missing link: a failure of fronto-hippocampal integration in schizophrenia
  publication-title: Neuroscience
  contributor:
    fullname: Fletcher
– volume: 202
  start-page: 809
  year: 1997
  end-page: 817
  ident: BIB23
  article-title: Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging
  publication-title: Radiology
  contributor:
    fullname: Weiner
– volume: 119
  start-page: 1667
  year: 1996
  end-page: 1675
  ident: BIB43
  article-title: Cerebral activation during performance of a card sorting test
  publication-title: Brain
  contributor:
    fullname: Kimura
– volume: 34
  start-page: 721
  year: 1995
  end-page: 727
  ident: BIB18
  article-title: Reversible decreases in
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: Arnold
– volume: 67
  start-page: 710
  year: 1999
  end-page: 715
  ident: BIB17
  article-title: Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup?
  publication-title: J. Neurol. Neurosurg. Psychiatry
  contributor:
    fullname: Miller
– volume: 7
  start-page: 169
  year: 1992
  end-page: 176
  ident: BIB8
  article-title: Wisconsin Card Sorting Test deficits in chronic paranoid schizophrenia. Evidence for a relatively discrete subgroup?
  publication-title: Schizophr. Res.
  contributor:
    fullname: Braff
– volume: 18
  start-page: 1
  year: 1998
  end-page: 9
  ident: BIB4
  article-title: Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia
  publication-title: Neuropsychopharmacology
  contributor:
    fullname: Weinberger
– volume: 156
  start-page: 286
  year: 1999
  end-page: 293
  ident: BIB35
  article-title: Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Remington
– volume: 17
  start-page: 49
  year: 1987
  end-page: 57
  ident: BIB37
  article-title: Schizophrenic syndromes, cognitive performance and neurological dysfunction
  publication-title: Psychol. Med.
  contributor:
    fullname: Liddle
– year: 1998
  ident: BIB27
  publication-title: Schizophrenia from a Neurocognitive Perspective
  contributor:
    fullname: Green
– volume: 43
  start-page: 97
  year: 2000
  end-page: 108
  ident: BIB52
  article-title: Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia
  publication-title: Schizophr. Res.
  contributor:
    fullname: Lieberman
– volume: 41
  start-page: 389
  year: 2000
  end-page: 395
  ident: BIB22
  article-title: Effects of age, medication, and illness duration on the
  publication-title: Schizophr. Res.
  contributor:
    fullname: Henn
– volume: 14
  start-page: 87
  year: 1996
  end-page: 96
  ident: BIB9
  article-title: Radioreceptor binding profile of the atypical antipsychotic olanzapine
  publication-title: Neuropsychopharmacology
  contributor:
    fullname: Wong
– volume: 45
  start-page: 660
  year: 1999
  end-page: 667
  ident: BIB6
  article-title: The relationship between dorsolateral prefrontal
  publication-title: Biol. Psychiatry
  contributor:
    fullname: Weinberger
– volume: 187
  start-page: 219
  year: 1993
  end-page: 227
  ident: BIB40
  article-title: Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra
  publication-title: Radiology
  contributor:
    fullname: Frahm
– volume: 57
  start-page: 62
  year: 1996
  end-page: 65
  ident: BIB25
  article-title: Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies
  publication-title: J. Clin. Psychiatry
  contributor:
    fullname: Weinberger
– volume: 40
  start-page: 87
  year: 1999
  end-page: 99
  ident: BIB28
  article-title: The neuropathological effects of antipsychotic drugs
  publication-title: Schizophr. Res.
  contributor:
    fullname: Harrison
– volume: 27
  start-page: 65
  year: 1997
  end-page: 71
  ident: BIB20
  article-title: Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia
  publication-title: Schizophr. Res.
  contributor:
    fullname: Weiner
– volume: 158
  start-page: 176
  year: 2001
  end-page: 184
  ident: BIB29
  article-title: Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment
  publication-title: Am. J. Psychiatry
  contributor:
    fullname: Keefe
– volume: 46
  start-page: 315
  year: 1992
  end-page: 328
  ident: BIB49
  article-title: Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine
  publication-title: Neuroscience
  contributor:
    fullname: Fibiger
– volume: 46
  start-page: 81
  year: 2000
  end-page: 89
  ident: BIB55
  article-title: Improvement in cognition associated with novel antipsychotic drugs: a direct drug effect or reduction of EPS?
  publication-title: Schizophr. Res.
  contributor:
    fullname: Davidson
– volume: 157
  start-page: 799
  year: 1990
  end-page: 811
  ident: BIB36
  article-title: The effect of neuroleptics on cognitive and psychomotor function
  publication-title: Br. J. Psychiatry
  contributor:
    fullname: King
– volume: 40
  start-page: 816
  year: 1998
  end-page: 821
  ident: BIB58
  article-title: Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: Maudsley
– volume: 277
  start-page: 953
  year: 1997
  end-page: 955
  ident: BIB34
  article-title: Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine
  publication-title: Science
  contributor:
    fullname: Roth
– volume: 27
  start-page: 377
  year: 1990
  end-page: 399
  ident: BIB47
  article-title: Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function
  publication-title: Biol. Psychiatry
  contributor:
    fullname: Raese
– volume: 384
  start-page: 95
  year: 1994
  end-page: 101
  ident: BIB39
  article-title: Recent advances in the pharmacotherapy of schizophrenia
  publication-title: Acta Psychiatr. Scand. Suppl.
  contributor:
    fullname: Ranjan
SSID ssj0015339
Score 1.9604901
Snippet Magnetic resonance spectroscopic imaging provides a non-invasive approach for testing the hypothesis that neuronal function can improve under atypical...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 145
SubjectTerms Adult
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Cell Survival - drug effects
Cell Survival - physiology
Chronic Disease
Cingulate gyrus
Cross-Sectional Studies
Female
Gyrus Cinguli - cytology
Gyrus Cinguli - drug effects
Gyrus Cinguli - metabolism
Humans
Magnetic Resonance Spectroscopy - statistics & numerical data
Male
Neuronal viability
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - metabolism
Schizophrenia - pathology
Spectroscopic imaging
WCST
Title Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia
URI https://dx.doi.org/10.1016/S0924-977X(02)00003-2
https://www.ncbi.nlm.nih.gov/pubmed/11872332
https://search.proquest.com/docview/71499185
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbK9sIF8WZ5FB9QBVLddZzEdrhVFauFVauqtGJvlmM7Ug5NVt0taC_8D_4t48c2cKiQOEVynInlmcwjnm8GoXfMFIJRK0iTs5wUtpKkBt6TxlS8YoI3Wnq888kpn10WXxblYgcdb7EwPq0y6f6o04O2TiOTtJuTZdtOvlIfOgixoB5tQnPQw7tgjpgcod2jz_PZ6e1hAng0seQeK4h_YADyRCJh8D1lHwIdwu4yUXe5oMEUTR-iB8mHxEdxmY_Qjuseo_2zWIR6c4AvBkzV6gDv47OhPPXmCfo1BVOWfsNi3VkcSlp6gt_bWLR7g_sGg2OIw663_TU2MNf3-XJp8go3ID_9j0hi3SYsV2vwbeL6R3xyTgKO09fL7Jdwr70KLZFw22ETa_Li1Z85f0_R5fTTxfGMpAYNxOQ8WxPDjM61MGXljBVGOuZxueAxOF5B6Kuptlww3dQQgttMykzIhhouIATT2oo6f4ZGXd-5FwhrLixljrNaMJCYsipKoWvDHTi0WV3YMTrc8kQtYx0ONSSoAROVZ6KiTAUmKjZGcss59ZdAKbAV_3r07ZbTCj42f4KiO9ffrBSsHPxpWY7R8ygAw1oyKVies5f__9pX6H5oNRPSgl6j0fr6xr0Bj2dd76F7hz-zvSTX_jo__zb_DRnIASc
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaq9gAXxJvlVR9QBVLNOk5iO9yqitWWdlcVbKW9WY7tSDmQrLpb0P4U_i3jxzZwqJC4JvbE8oxnvonngdA7ZgrBqBWkyVlOCltJUgPvSWMqXjHBGy19vvNszqdXxZdludxDp7tcGB9WmXR_1OlBW6cn47Sb41Xbjr9R7zoIsaQ-24TmoIcPAA1UcDoPTs7Op_PbywRANLHkHiuInzAk8kQi4eF7yj4EOoTdZaLugqDBFE0eogcJQ-KTuMxHaM91j9HRZSxCvT3GiyGnan2Mj_DlUJ56-wT9moApS79hse4sDiUtPcEfbSzavcV9gwEY4rDrbX-NDYz1fb5cGrzGDchP_zOS2LQpl6s1-DZw_ROefSUhj9PXy-xX8K79Hloi4bbDJtbkxes_Y_6eoqvJ58XplKQGDcTkPNsQw4zOtTBl5YwVRjrm83IBMThegeurqbZcMN3U4ILbTMpMyIYaLsAF09qKOn-G9ru-cy8Q1lxYyhxntWAgMWVVlELXhjsAtFld2BH6uOOJWsU6HGoIUAMmKs9ERZkKTFRshOSOc-ovgVJgK_419XDHaQWHzd-g6M71N2sFKwc8LcsReh4FYFhLJgXLc_by_z97iO5NF7MLdXE2P3-F7oe2MyFE6DXa31zfuDeAfjb12yTdvwFFzQF4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functioning+and+neuronal+viability+of+the+anterior+cingulate+neurons+following+antipsychotic+treatment%3A+MR-spectroscopic+imaging+in+chronic+schizophrenia&rft.jtitle=European+neuropsychopharmacology&rft.au=Braus%2C+Dieter+F&rft.au=Ende%2C+Gabriele&rft.au=Weber-Fahr%2C+Wolfgang&rft.au=Demirakca%2C+Traute&rft.date=2002-04-01&rft.issn=0924-977X&rft.volume=12&rft.issue=2&rft.spage=145&rft_id=info:doi/10.1016%2FS0924-977X%2802%2900003-2&rft_id=info%3Apmid%2F11872332&rft.externalDocID=11872332
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0924-977X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0924-977X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0924-977X&client=summon