Genetic mutations as a cause of hyperinsulinemic hypoglycemia in children

Hyperinsulinemic hypoglycemia in children is associated with unregulated secretion of insulin and hypoglycemia, a condition that is now known to be genetically diverse. This article reviews recent progress that has elucidated several beta-cell molecular defects responsible for the pathogenesis of th...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 28; no. 3; p. 647
Main Author Thomas, P M
Format Journal Article
LanguageEnglish
Published United States 01.09.1999
Subjects
Child
Chromosomes, Human, Pair 11 - genetics
Glucokinase - genetics
Humans
Hyperinsulinism - genetics
Hypoglycemia - genetics
Loss of Heterozygosity
Mutation
Quaternary Ammonium Compounds - blood
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Summary:Hyperinsulinemic hypoglycemia in children is associated with unregulated secretion of insulin and hypoglycemia, a condition that is now known to be genetically diverse. This article reviews recent progress that has elucidated several beta-cell molecular defects responsible for the pathogenesis of this disorder.
ISSN:0889-8529
1558-4410
DOI:10.1016/S0889-8529(05)70092-X