MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker

• Published in: Cell chemical biology Vol. 25; no. 4; pp. 483 - 493.e9
• Main Authors: Anderson, Mark C., Chaze, Thibault, Coïc, Yves-Marie, Injarabian, Louise, Jonsson, Friederike, Lombion, Naelle, Selimoglu-Buet, Dorothée, Souphron, Judith, Ridley, Caroline, Vonaesch, Pascale, Baron, Bruno, Arena, Ellen T., Tinevez, Jean-Yves, Nigro, Giulia, Nothelfer, Katharina, Solary, Eric, Lapierre, Valérie, Lazure, Thierry, Matondo, Mariette, Thornton, David, Sansonetti, Philippe J., Baleux, Françoise, Marteyn, Benoit S.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 19.04.2018; Cell Press
• Subjects: Adult; Animals; Biochemistry, Molecular Biology; biomarker; Biomarkers; Carbocyanines; Dysentery, Bacillary; Female; Fluorescent Dyes; Guinea Pigs; Humans; imaging; Immunology; Inflammation; Lactoferrin; Life Sciences; Mice; Mice, Inbred C57BL; Middle Aged; MUB40; neutrophil; Neutrophils; Peptides; Rabbits; Shigella; lactoferrin; MUB40; biomarker; neutrophil; imaging; MUB

Neutrophils represent the most abundant immune cells recruited to inflamed tissues. A lack of dedicated tools has hampered their detection and study. We show that a synthesized peptide, MUB40, binds to lactoferrin, the most abundant protein stored in neutrophil-specific and tertiary granules. Lactof...