Sleep terrors in children: a prospective study of twins
There is growing evidence that genetic factors are involved in the occurrence of sleep terrors. Twin studies provide invaluable information regarding genetic and environmental factors that can affect the manifestation of the disease; however, most previous twin studies on sleep terrors were performe...
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Published in | Pediatrics (Evanston) Vol. 122; no. 6; p. e1164 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2008
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Subjects | |
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Abstract | There is growing evidence that genetic factors are involved in the occurrence of sleep terrors. Twin studies provide invaluable information regarding genetic and environmental factors that can affect the manifestation of the disease; however, most previous twin studies on sleep terrors were performed retrospectively or with a sample that was too small to yield conclusive results. The aim of this large prospective study was to clarify the genetic and environmental contributions to sleep terrors in childhood.
In all, 390 pairs of monozygotic and dizygotic twins were recruited at birth for a longitudinal study. The prevalence and frequency of sleep terrors were assessed at 18 and 30 months of age with a questionnaire administered to the biological mother of the twins. Zygosity was determined by a questionnaire and genotyping. The prevalence and polychoric correlation for each type of twins were calculated. Structural-equation modeling was used to determine the proportion of variance attributable to additive genetic, shared, and nonshared environmental factors.
The prevalence of sleep terrors was 36.9% at 18 months and 19.7% at 30 months; 49% of affected children were boys, and 51% were girls. At 18 months, the polychoric correlations were 0.63 for monozygotic and 0.36 for the dizygotic twins. These were 0.68 (monozygotic) and 0.24 (dizygotic) at 30 months. Our model-fitting analysis showed that sleep terrors were explained by a 2-component model at 18 months (43.7% additive genetic effects and 56.3% nonshared environment) and at 30 months (41.5% additive genetic effects and 58.5% nonshared environment).
These results strongly support the heritability of sleep terrors. There also seems to be continuity in genetic effects with the persistence of sleep-terror symptoms. |
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AbstractList | There is growing evidence that genetic factors are involved in the occurrence of sleep terrors. Twin studies provide invaluable information regarding genetic and environmental factors that can affect the manifestation of the disease; however, most previous twin studies on sleep terrors were performed retrospectively or with a sample that was too small to yield conclusive results. The aim of this large prospective study was to clarify the genetic and environmental contributions to sleep terrors in childhood.
In all, 390 pairs of monozygotic and dizygotic twins were recruited at birth for a longitudinal study. The prevalence and frequency of sleep terrors were assessed at 18 and 30 months of age with a questionnaire administered to the biological mother of the twins. Zygosity was determined by a questionnaire and genotyping. The prevalence and polychoric correlation for each type of twins were calculated. Structural-equation modeling was used to determine the proportion of variance attributable to additive genetic, shared, and nonshared environmental factors.
The prevalence of sleep terrors was 36.9% at 18 months and 19.7% at 30 months; 49% of affected children were boys, and 51% were girls. At 18 months, the polychoric correlations were 0.63 for monozygotic and 0.36 for the dizygotic twins. These were 0.68 (monozygotic) and 0.24 (dizygotic) at 30 months. Our model-fitting analysis showed that sleep terrors were explained by a 2-component model at 18 months (43.7% additive genetic effects and 56.3% nonshared environment) and at 30 months (41.5% additive genetic effects and 58.5% nonshared environment).
These results strongly support the heritability of sleep terrors. There also seems to be continuity in genetic effects with the persistence of sleep-terror symptoms. |
Author | Paquet, Jean Petit, Dominique Boivin, Michel Montplaisir, Jacques Pérusse, Daniel Tremblay, Richard E Nguyen, Bich Hong |
Author_xml | – sequence: 1 givenname: Bich Hong surname: Nguyen fullname: Nguyen, Bich Hong organization: Sleep Disorders Center, Sacre-Coeur Hospital, 5400 Gouin Blvd W, Montreal, Quebec, Canada H4J 1C5 – sequence: 2 givenname: Daniel surname: Pérusse fullname: Pérusse, Daniel – sequence: 3 givenname: Jean surname: Paquet fullname: Paquet, Jean – sequence: 4 givenname: Dominique surname: Petit fullname: Petit, Dominique – sequence: 5 givenname: Michel surname: Boivin fullname: Boivin, Michel – sequence: 6 givenname: Richard E surname: Tremblay fullname: Tremblay, Richard E – sequence: 7 givenname: Jacques surname: Montplaisir fullname: Montplaisir, Jacques |
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SubjectTerms | Age Distribution Child, Preschool Female Genetic Predisposition to Disease - epidemiology Humans Infant Longitudinal Studies Male Night Terrors - epidemiology Night Terrors - genetics Prevalence Prospective Studies Quebec Risk Assessment Sex Distribution Twins - genetics Twins, Dizygotic - genetics Twins, Monozygotic |
Title | Sleep terrors in children: a prospective study of twins |
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