Cytotoxicity and mode of action of vanada- and niobatricarbadecaboranyl monohalide complexes in human HL-60 promyelocytic leukemia cells

• Published in: Journal of inorganic biochemistry Vol. 93; no. 3; pp. 125 - 131
• Main Authors: Hall, Iris H., Durham, Richard W., Tram, Min, Mueller, Stephanie, Ramachandran, Bhaskar M., Sneddon, Larry G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2003
• Subjects: Anti-leukemic drugs; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Caspase Inhibitors; Cell Division - drug effects; Drug Screening Assays, Antitumor; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute - drug therapy; Leukemia, Promyelocytic, Acute - pathology; Niobium - chemistry; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Topoisomerase I Inhibitors; Vanada- and niobatricarbadecaboranyl monohalide complexes; Vanadium - chemistry; Vanada- and niobatricarbadecaboranyl monohalide complexes; Anti-leukemic drugs; Caspase inhibitors

Vanada- and niobatricarbadecaboranyl monohalide complexes proved to be potent cytotoxic agents against murine and human leukemia and lymphoma growth as well as HeLa suspended uterine carcinoma. The vanada complex reduced the growth of KB nasopharynx, Hepe liver, HCT-8 ileum and 1-A9 ovary solid carc...