Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study

• Published in: Journal of rheumatology Vol. 38; no. 12; p. 2653
• Main Authors: Moldofsky, Harvey, Harris, Herbert W, Archambault, W Tad, Kwong, Terence, Lederman, Seth
• Format: Journal Article
• Language: English
• Published: Canada 01.12.2011
• Subjects: Adult; Aged; Amitriptyline - analogs & derivatives; Amitriptyline - pharmacology; Amitriptyline - therapeutic use; Double-Blind Method; Electroencephalography; Fatigue - drug therapy; Fatigue - etiology; Female; Fibromyalgia - complications; Fibromyalgia - drug therapy; Fibromyalgia - physiopathology; Humans; Male; Middle Aged; Placebos - therapeutic use; Sleep - drug effects; Sleep - physiology; Sleep Wake Disorders - drug therapy; Sleep Wake Disorders - etiology; Sleep Wake Disorders - physiopathology; Treatment Outcome

To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening. Of 37 patients with FM in the screened population, 36 were...