Active targeting of gold nanoparticles as cancer therapeutics

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, wit...

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Bibliographic Details
Published inChemical Society reviews Vol. 49; no. 23; pp. 8774 - 8789
Main Authors Goddard, Zoë Rachael, Marín, María J., Russell, David A., Searcey, Mark
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 07.12.2020
Subjects
Antibodies
biocompatibility
Cancer
Carbohydrates
Drug carriers
Gold
Ligands
moieties
nanogold
Nanoparticles
neoplasms
oligonucleotides
Peptides
proteins
society
Toxicity
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Summary:Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.
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ISSN:0306-0012
1460-4744
1460-4744
DOI:10.1039/D0CS01121E