Binding studies on peptide–oligonucleotide complex: intercalation of tryptophan in GC-rich region of c- myc gene

• Published in: Biochimica et biophysica acta Vol. 1622; no. 2; pp. 73 - 81
• Main Authors: Aklank Jain, Akanchha, Rajeswari, Moganty R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 23.07.2003
• Subjects: Binding studies; c- myc; Circular Dichroism; GC Rich Sequence; Genes, myc; Hot Temperature; Oligonucleotide; Oligonucleotides - chemistry; Oligopeptides - chemistry; Peptide; Spectrophotometry, Ultraviolet; Thermodynamics; Tryptophan - chemistry; Tryptophan intercalation; Tryptophan intercalation; Oligonucleotide; c- myc; Peptide; Binding studies

Transcriptional regulation of the c- myc gene is essential for normal cellular proliferation; differentiation and overexpression of c- myc is associated with several human cancers. C- myc gene, particularly exon 1, which contains the conserved P1 and P2 promoter regions, has been a potential target...