Cellular balance of glutathione levels through the expression of γ-glutamylcysteine synthetase and glutathione thiol transferase genes in human hepatic cells resistant to a glutathione poison - Tanaka, Toshiya; Uchiumi, Takeshi; Nomoto, Minoru; Kohno, Kimitoshi; Kondo, Takahito; Nishio, Kazuto; Saijo, Nagahiro; Kuwano, Michihiko (Biochimica et biophysica acta, 1999)
Keywords: Buthionine sulfoximine; Buthionine Sulfoximine - chemistry; Drug Resistance; Gene Expression Regulation; Glutamate-Cysteine Ligase - genetics; Glutathione; Glutathione - analysis; Glutathione - chemistry; Glutathione Peroxidase - genetics; Glutathione S-transferase; Glutathione Transferase - genetics; Hepatic cell (Human); Humans; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos - analysis; Proto-Oncogene Proteins c-jun - analysis; RNA, Messenger - analysis; Transcription; Transfection; Tumor Cells, Cultured; γ-Glutamylcysteine synthetase; GSH, reduced glutathione; Transcription; GST, glutathione S-transferase; γ-Glutamylcysteine synthetase; MEM, minimum essential medium; BSO, dl-buthionine-[ S, R]-sulfoximine; Buthionine sulfoximine; GPX, glutathione peroxidase; Hepatic cell (Human); GCSl, GCS light subunit; GCS, γ-glutamylcysteine synthetase; GSTP1, P i class GST; Glutathione S-transferase; GCSh, GCS heavy subunit; Glutathione