Postbiotics: Metabolites and mechanisms involved in microbiota-host interactions

• Published in: Trends in food science & technology Vol. 108; pp. 11 - 26
• Main Authors: Peluzio, Maria do Carmo Gouveia, Martinez, J. Alfredo, Milagro, Fermin I.
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Ltd 01.02.2021; Elsevier BV
• Subjects: Antibiotics; Antiinfectives and antibacterials; Antioxidants; Apoptosis; Appetite; Autism; Bacteriocins; bile; Bile acids; biochemical pathways; Brain; Carbohydrates; Cardiovascular diseases; Cell proliferation; Cresols; Digestive system; Energy sources; Environmental changes; Epigenetics; Fatty acids; Fermentation; Fibers; food science; Gastrointestinal tract; glucose; Glucose metabolism; habitats; Holobiont; Homeostasis; human health; humans; Immune response; Intestinal microflora; intestinal microorganisms; Intestine; intestines; Kidney diseases; kidneys; Lipids; Metabolites; metabolomics; Metagenomics; Microbiota; Modulation; Nucleic acids; Nutrition; Nutrition research; p-cresol; Pathogens; Polyamines; Polyphenols; primary energy; Proteins; Short-chain fatty acids; therapeutics; Trimethylamine; ADC; NCDs; AHR; ODC; PRR; TNBS-N-oxide; MAMP; Polyphenols; AID; HDACi; PPAR-γ; PSA; Th2; UT; Short-chain fatty acids; QS; Holobiont; IAA; IS; LGG; CVD; ERK1/2; BCAAs; CRC; LTA; AMPK; SAM; PPA; TMAO; FXR; PCS; ABC; NAFLD; IBD; cAMP; THC; DHR; AAD-antibiotic; ASD; AAs; DMB; IBS; TLR; TDO; CDCA; CD; GI; TMA; Gastrointestinal tract; GOS; FMO3; LAB; TA; Trimethylamine; SCFAs; Bacteriocins

The knowledge on the mechanisms through which the metabolites produced by the gut microbiota (postbiotics) prevent diseases, induce therapeutic responses, and behave differently in response to dietary and environmental changes, is one of the major challenges in nutrition research and paves the route...