Effects of MC-100093 on Ethanol Drinking and the Expression of Astrocytic Glutamate Transporters in the Mesocorticolimbic Brain Regions of Male and Female Alcohol-Preferring Rats

• Published in: Neuroscience Vol. 552; pp. 89 - 99
• Main Authors: Alotaibi, Ahmed, Travaglianti, Shelby, Wong, Woonyen, Abou-Gharbia, Magid, Childers, Wayne, Sari, Youssef
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2024
• Subjects: Alcohol Drinking - metabolism; Animals; Astrocytes - drug effects; Astrocytes - metabolism; Central Nervous System Depressants - administration & dosage; Central Nervous System Depressants - pharmacology; Ethanol - administration & dosage; Ethanol - pharmacology; ethanol dependence; Excitatory Amino Acid Transporter 2 - biosynthesis; Excitatory Amino Acid Transporter 2 - metabolism; Female; GLT-1; glutamate; Male; nucleus accumbens; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Rats; Sex Characteristics; xCT; NAc; mPFC; NAc-core; xCT; nucleus accumbens; ethanol dependence; NAc-shell; glutamate; GLT-1

•MC-100093 reduced ethanol intake in both female and male P rats.•Chronic ethanol intake reduced GLT-1 and xCT in mPFC-IL/PL in males.•Chronic ethanol intake reduced GLT-1 in mPFC-IL and xCT in mPFC-IL/PL in females.•MC-100093 upregulated GLT-1 and xCT in mPFC and NAc in females and males. Chronic e...