Transport Characteristics of a Novel Peptide Transporter 1 Substrate, Antihypotensive Drug Midodrine, and Its Amino Acid Derivatives

Midodrine is an oral drug for orthostatic hypotension. This drug is almost completely absorbed after oral administration and converted into its active form, 1-(2′,5′-dimethoxyphenyl)-2-aminoethanol) (DMAE), by the cleavage of a glycine residue. The intestinal H + -coupled peptide transporter 1 (...

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Published inThe Journal of pharmacology and experimental therapeutics Vol. 318; no. 1; pp. 455 - 460
Main Authors Tsuda, Masahiro, Terada, Tomohiro, Irie, Megumi, Katsura, Toshiya, Niida, Ayumu, Tomita, Kenji, Fujii, Nobutaka, Inui, Ken-ichi
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.07.2006
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