Reduced MicroRNA-150 Is Associated with Poor Survival in Pulmonary Arterial Hypertension

• Published in: American journal of respiratory and critical care medicine Vol. 187; no. 3; pp. 294 - 302
• Main Authors: Rhodes, Christopher J., Wharton, John, Boon, Reinier A., Roexe, Tino, Tsang, Hilda, Wojciak-Stothard, Beata, Chakrabarti, Anob, Howard, Luke S., Gibbs, J. Simon R., Lawrie, Allan, Condliffe, Robin, Elliot, Charles A., Kiely, David G., Huson, Les, Ghofrani, Hossein A., Tiede, Henning, Schermuly, Ralph, Zeiher, Andreas M., Dimmeler, Stefanie, Wilkins, Martin R.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.02.2013
• Subjects: Adult; Age Distribution; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cohort Studies; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - genetics; Intensive care medicine; London; Lungs; Male; Medical sciences; Microarray Analysis - methods; MicroRNAs; MicroRNAs - blood; Middle Aged; Mortality; Pathogenesis; Patients; Plasma; Pneumology; Polymerase Chain Reaction - methods; Proteins; Pulmonary arteries; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Rats; ROC Curve; Severity of Illness Index; Survival Analysis; London; United Kingdom > UK; Germany; prognostic biomarkers; Intensive care; Prognosis; Respiratory disease; Cardiovascular disease; miR-150; microRNA; Survival; Pulmonary hypertension; Resuscitation

MicroRNAs (miRNAs or miRs) are implicated in the pathogenesis of various cardiovascular diseases, including pulmonary arterial hypertension (PAH). We sought to measure changes in plasma levels of miRNAs in patients with PAH and relate them to the severity of the disease. A microarray screen was perf...