Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor

• Published in: The Korean journal of pain Vol. 23; no. 4; pp. 236 - 241
• Main Authors: Choi, Cheol Hun, Kim, Woong Mo, Lee, Hyung Gon, Jeong, Cheol Won, Kim, Chang Mo, Lee, Seong Heon, Yoon, Myung Ha
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Pain Society 01.12.2010; 대한통증학회
• Subjects: Original; 마취과학; intrathecal; cyclooxygenase; antinociception; opioid receptor subtype

Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis, evidences suggesting endogenous opioid peptide link in spinal antinociception of COX i...