Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways

• Published in: European neuropsychopharmacology Vol. 10; no. 3; pp. 205 - 209
• Main Authors: Frisch, A, Michaelovsky, E, Rockah, R, Amir, I, Hermesh, H, Laor, N, Fuchs, C, Zohar, J, Lerer, B, Buniak, S.F, Landa, S, Poyurovsky, M, Shapira, B, Weizman, R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2000
• Subjects: Carrier Proteins - genetics; Dopamine D4 receptor (DRD4); Dopamine Plasma Membrane Transport Proteins; Dopamine transporter (DAT1); Humans; Jews - genetics; Membrane Glycoproteins - genetics; Membrane Transport Proteins; Nerve Tissue Proteins; Obsessive-Compulsive Disorder - genetics; Polymorphism, Genetic - genetics; Receptors, Dopamine - genetics; Receptors, Serotonin - genetics; Serotonin 2A receptor (HTR2A); Serotonin 2C receptor (HTR2C); Serotonin Plasma Membrane Transport Proteins; Serotonin transporter (5-HTT); Tryptophan hydroxylase (TPH); Serotonin transporter (5-HTT); Tryptophan hydroxylase (TPH); Serotonin 2A receptor (HTR2A); Serotonin 2C receptor (HTR2C); Dopamine D4 receptor (DRD4); Dopamine transporter (DAT1)

Obsessive-compulsive disorder (OCD) is a severe and disabling anxiety disorder with a marked genetic contribution. Pharmacological data indicated involvement of the serotonergic and dopaminergic systems. We studied the association between OCD and six candidate genes encoding important components of...