Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study

• Published in: Journal of rheumatology Vol. 37; no. 10; p. 2156
• Main Authors: Moldofsky, Harvey, Inhaber, Neil H, Guinta, Diane R, Alvarez-Horine, Sarah B
• Format: Journal Article
• Language: English
• Published: Canada 01.10.2010
• Subjects: Adjuvants, Anesthesia - pharmacology; Adjuvants, Anesthesia - therapeutic use; Adult; Double-Blind Method; Female; Fibromyalgia - complications; Fibromyalgia - drug therapy; Humans; Male; Middle Aged; Placebos - pharmacology; Placebos - therapeutic use; Polysomnography; Sleep - drug effects; Sleep Wake Disorders - drug therapy; Sleep Wake Disorders - etiology; Sodium Oxybate - pharmacology; Sodium Oxybate - therapeutic use; Surveys and Questionnaires; Treatment Outcome

To determine the effects of sodium oxybate (SXB) on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome (FM). Of 304 patients with FM (American College of Rheumatology tender point criteria) in the screened study population, 209 underwent polysomnography, 195 were...