Daunomycin-polypeptide conjugates with antitumor activity

• Published in: Biochimica et biophysica acta Vol. 1798; no. 12; pp. 2209 - 2216
• Main Authors: Szabó, Rita, Bánóczi, Zoltán, Mező, Gábor, Láng, Orsolya, Kőhidai, László, Hudecz, Ferenc
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2010
• Subjects: Animals; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Branched polypeptide conjugates; Cell-Penetrating Peptides - chemistry; Cell-Penetrating Peptides - pharmacology; Daunomycin; Daunorubicin - chemistry; Daunorubicin - pharmacology; Dose-Response Relationship, Drug; Female; HL-60 Cells; Humans; In vitro biological effect; Leukemia cell lines; Macrophage; Macrophages - metabolism; Macrophages - pathology; Mice; Time Factors; Daunomycin; In vitro biological effect; Branched polypeptide conjugates; Leukemia cell lines; Macrophage

We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or anionic branched polypeptides and a new conjugate containing a cationic polypeptide carrier modified with a cell penetrating octaarginine. We investigated in vitro physiological...