Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease

• Published in: Brain (London, England : 1878) Vol. 141; no. 9; pp. 2740 - 2754
• Main Authors: Dani, Melanie, Wood, Melanie, Mizoguchi, Ruth, Fan, Zhen, Walker, Zuzana, Morgan, Richard, Hinz, Rainer, Biju, Maya, Kuruvilla, Tarun, Brooks, David J, Edison, Paul
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2018
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid - metabolism; Amyloid beta-Peptides - metabolism; Amyloid beta-Peptides - physiology; Amyloidosis - pathology; Brain - pathology; Brain Mapping - methods; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Disease Progression; Female; Humans; Magnetic Resonance Imaging - methods; Male; Microglia - metabolism; Microglia - physiology; Middle Aged; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - physiology; Neuropsychological Tests; Plaque, Amyloid - pathology; Positron-Emission Tomography - methods; tau Proteins - metabolism; tau Proteins - physiology; tau; amyloid; microglia; imaging; Alzheimer's disease; PET

The relationship between microglial activation and protein aggregation in Alzheimer's disease is still debated. Dani et al. report that in vivo microglial activation strongly correlates with tau aggregation and amyloid deposition in both mild cognitive impairment and Alzheimer's disease. A...