Anti-hepatic carcinoma mechanisms of calycosin through targeting ferroptosis
Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural compound with antioxidant and anti-inflammatory activities, has promising antitumor effects. However, the ferroptosis-related mechanism of calycosin in...
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Published in | Intelligent medicine Vol. 3; no. 3; pp. 173 - 179 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.08.2023
Elsevier |
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Abstract | Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural compound with antioxidant and anti-inflammatory activities, has promising antitumor effects. However, the ferroptosis-related mechanism of calycosin in the treatment of hepatic carcinoma has not been reported.
This study applied network pharmacology and bioinformatic approaches (including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis) to investigate the pharmacologic targets and mechanism of action of calycosin in the treatment of hepatic carcinoma through targeting ferroptosis. By searching online databases including The Cancer Genome Atlas, FerrDb, GeneCards, SwissTargetPrediction, SuperPred, BindingDB, TargetNet, BATMAN-TCM, and Drugbank, we identified 13 ferroptosis-related putative target genes of calycosin against hepatic carcinoma including IL-6, PTGS2, SRC, HRAS, NQO1, NOX4, PGK1, G6PD, GPI, MIF, NOS2, ALDOA, and SQSTM1.
Molecular docking analysis revealed that calycosin potentially binded directly with the target proteins IL-6, PTGS2, and SRC. Functional enrichment analysis of these proteins indicated that they were involved in gluconeogenesis and apoptosis through regulation of ERK1, ERK2, and MAPK activities (P < 0.05).
Calycosin exerts antitumor effects in hepatic carcinoma by targeting ferroptosis through regulation of IL-6, PTGS2, and SRC. |
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AbstractList | Background: Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural compound with antioxidant and anti-inflammatory activities, has promising antitumor effects. However, the ferroptosis-related mechanism of calycosin in the treatment of hepatic carcinoma has not been reported. Methods: This study applied network pharmacology and bioinformatic approaches (including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis) to investigate the pharmacologic targets and mechanism of action of calycosin in the treatment of hepatic carcinoma through targeting ferroptosis. By searching online databases including The Cancer Genome Atlas, FerrDb, GeneCards, SwissTargetPrediction, SuperPred, BindingDB, TargetNet, BATMAN-TCM, and Drugbank, we identified 13 ferroptosis-related putative target genes of calycosin against hepatic carcinoma including IL-6, PTGS2, SRC, HRAS, NQO1, NOX4, PGK1, G6PD, GPI, MIF, NOS2, ALDOA, and SQSTM1. Results: Molecular docking analysis revealed that calycosin potentially binded directly with the target proteins IL-6, PTGS2, and SRC. Functional enrichment analysis of these proteins indicated that they were involved in gluconeogenesis and apoptosis through regulation of ERK1, ERK2, and MAPK activities (P < 0.05). Conclusion: Calycosin exerts antitumor effects in hepatic carcinoma by targeting ferroptosis through regulation of IL-6, PTGS2, and SRC. Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural compound with antioxidant and anti-inflammatory activities, has promising antitumor effects. However, the ferroptosis-related mechanism of calycosin in the treatment of hepatic carcinoma has not been reported. This study applied network pharmacology and bioinformatic approaches (including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis) to investigate the pharmacologic targets and mechanism of action of calycosin in the treatment of hepatic carcinoma through targeting ferroptosis. By searching online databases including The Cancer Genome Atlas, FerrDb, GeneCards, SwissTargetPrediction, SuperPred, BindingDB, TargetNet, BATMAN-TCM, and Drugbank, we identified 13 ferroptosis-related putative target genes of calycosin against hepatic carcinoma including IL-6, PTGS2, SRC, HRAS, NQO1, NOX4, PGK1, G6PD, GPI, MIF, NOS2, ALDOA, and SQSTM1. Molecular docking analysis revealed that calycosin potentially binded directly with the target proteins IL-6, PTGS2, and SRC. Functional enrichment analysis of these proteins indicated that they were involved in gluconeogenesis and apoptosis through regulation of ERK1, ERK2, and MAPK activities (P < 0.05). Calycosin exerts antitumor effects in hepatic carcinoma by targeting ferroptosis through regulation of IL-6, PTGS2, and SRC. |
Author | Nie, Litao Zhou, Rui Liang, Xiao Liao, Yimei Su, Min Wan, Xiaowei Li, Xin |
Author_xml | – sequence: 1 givenname: Litao surname: Nie fullname: Nie, Litao organization: Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, China – sequence: 2 givenname: Yimei surname: Liao fullname: Liao, Yimei organization: Department of Clinical Pharmacy, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi Zhuang Autonomous Region 537100, China – sequence: 3 givenname: Rui surname: Zhou fullname: Zhou, Rui organization: Department of Hepatobiliary Surgery, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi Zhuang Autonomous Region 537199, China – sequence: 4 givenname: Xiao surname: Liang fullname: Liang, Xiao organization: Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, China – sequence: 5 givenname: Xiaowei surname: Wan fullname: Wan, Xiaowei organization: Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, China – sequence: 6 givenname: Xin surname: Li fullname: Li, Xin organization: Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, China – sequence: 7 givenname: Min surname: Su fullname: Su, Min organization: Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, China |
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Keywords | Pharmacologic target Ferroptosis Calycosin Bioinformatics Hepatic carcinoma |
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Snippet | Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural compound... Background: Ferroptosis, a pathologic state induced by lipid-driven oxidative stress, is associated with the development of human cancers. Calycosin, a natural... |
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StartPage | 173 |
SubjectTerms | Bioinformatics Calycosin Ferroptosis Hepatic carcinoma Pharmacologic target |
Title | Anti-hepatic carcinoma mechanisms of calycosin through targeting ferroptosis |
URI | https://dx.doi.org/10.1016/j.imed.2022.06.001 https://doaj.org/article/7878de01465c4fa29ebff2df268a8075 |
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