Perioperative Single Dose Systemic Dexamethasone for Postoperative Pain A Meta-analysis of Randomized Controlled Trials

• Published in: Anesthesiology (Philadelphia) Vol. 115; no. 3; pp. 575 - 588
• Main Authors: De Oliveira, Gildàsio S., Almeida, Marcela D., Benzon, Honorio T., McCarthy, Robert J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.09.2011
• Subjects: Analgesics, Opioid - administration & dosage; Analgesics, Opioid - therapeutic use; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Chronic Disease; Data Interpretation, Statistical; Dexamethasone - administration & dosage; Dexamethasone - adverse effects; Dexamethasone - therapeutic use; Dose-Response Relationship, Drug; Humans; Medical sciences; Movement; Pain, Postoperative - drug therapy; Patient Discharge; Randomized Controlled Trials as Topic; Reproducibility of Results; Rest; Time Factors; Treatment Outcome; Postoperative; Corticosteroid; Dexamethasone; Pain; Steroid hormone; Antiinflammatory agent; Single dose; Anesthesia

Dexamethasone is frequently administered in the perioperative period to reduce postoperative nausea and vomiting. In contrast, the analgesic effects of dexamethasone are not well defined. The authors performed a meta-analysis to evaluate the dose-dependent analgesic effects of perioperative dexameth...