Neuropathogenesis of a mouse-adapted porcine epidemic diarrhea virus infection in suckling mice

• Published in: Journal of general virology Vol. 94; no. 4; pp. 831 - 836
• Main Authors: Kotani, Osamu, Shirato, Kazuya, Nagata, Noriyo, Ikeda, Hidetoshi, Takahashi, Kimimasa, Taguchi, Fumihiro
• Format: Journal Article
• Language: English
• Published: England 01.04.2013
• Subjects: Animals; Animals, Newborn; Astrocytes - virology; Brain - pathology; Brain - virology; Mice; Nervous System Diseases - pathology; Nervous System Diseases - virology; Neural Stem Cells - virology; Neurons - virology; Porcine epidemic diarrhea virus - pathogenicity; Virulence

A mouse-adapted porcine epidemic diarrhea virus, MK-p10, showed higher neurovirulence in suckling mice than a non-adapted MK strain. There was no difference in virus growth, whereas clear differences between these two virus infections existed in the type of target cells infected, the spread of virus...