STEMI—The importance of balance between antithrombotic treatment and bleeding risk
Abstract The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100 000 of population/year, with 6–12% hospital mortality in unselected patients [1] . Modern treatment strategies for STEMI are based on immediate antithrombotic treatment and primary percutaneous coronary i...
Saved in:
| Published in | Cor et vasa (English ed.) Vol. 55; no. 2; pp. e135 - e146 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Urban & Partner Sp. z o.o
01.04.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100 000 of population/year, with 6–12% hospital mortality in unselected patients [1] . Modern treatment strategies for STEMI are based on immediate antithrombotic treatment and primary percutaneous coronary intervention (PCI) with stent implantation. Therapy with a combination of two or even three more potent antiplatelet and anticoagulant agents reduces both short-term and long-term ischemic risk, morbidity and mortality; on the other hand it is associated with higher risks of bleeding. The first part of this review is focused on the pathogenesis of thrombi in STEMI patients and antithrombotic drugs currently used to treat STEMI patients. In the second part we discuss several factors that can affect bleeding risks including the choice of access site for coronary angiography, prevention and treatment of bleeding in STEMI patients. Finding a balance which minimizes both thrombotic and bleeding risk is crucial, although, it can be difficult and further randomized studies directed at finding this balance are needed. |
|---|---|
| AbstractList | Abstract The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100 000 of population/year, with 6–12% hospital mortality in unselected patients [1] . Modern treatment strategies for STEMI are based on immediate antithrombotic treatment and primary percutaneous coronary intervention (PCI) with stent implantation. Therapy with a combination of two or even three more potent antiplatelet and anticoagulant agents reduces both short-term and long-term ischemic risk, morbidity and mortality; on the other hand it is associated with higher risks of bleeding. The first part of this review is focused on the pathogenesis of thrombi in STEMI patients and antithrombotic drugs currently used to treat STEMI patients. In the second part we discuss several factors that can affect bleeding risks including the choice of access site for coronary angiography, prevention and treatment of bleeding in STEMI patients. Finding a balance which minimizes both thrombotic and bleeding risk is crucial, although, it can be difficult and further randomized studies directed at finding this balance are needed. The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100000 of population/year, with 6–12% hospital mortality in unselected patients [1]. Modern treatment strategies for STEMI are based on immediate antithrombotic treatment and primary percutaneous coronary intervention (PCI) with stent implantation. Therapy with a combination of two or even three more potent antiplatelet and anticoagulant agents reduces both short-term and long-term ischemic risk, morbidity and mortality; on the other hand it is associated with higher risks of bleeding. The first part of this review is focused on the pathogenesis of thrombi in STEMI patients and antithrombotic drugs currently used to treat STEMI patients. In the second part we discuss several factors that can affect bleeding risks including the choice of access site for coronary angiography, prevention and treatment of bleeding in STEMI patients. Finding a balance which minimizes both thrombotic and bleeding risk is crucial, although, it can be difficult and further randomized studies directed at finding this balance are needed. |
| Author | Bernat, Ivo Rokyta, Richard Hromadka, Milan Pospisil, Jan |
| Author_xml | – sequence: 1 fullname: Pospisil, Jan – sequence: 2 fullname: Hromadka, Milan – sequence: 3 fullname: Bernat, Ivo – sequence: 4 fullname: Rokyta, Richard |
| BookMark | eNqVkE1OwzAQhS1UJErpDVjkAglj53-DhKoClYpYtKwtx55Sp6lT2aaIHYfghJwEh3IBZjMzGr2ned8lGZneICHXFBIKtLhpE2mPwomEAU0TYAlAdkbGtII0LkvKRmQMQCGuihwuyNS5FkIVrARKx2S9Ws-fFt-fX-stRnp_6K0XRmLUb6JGdL9jg_4d0UTCeO23tt83vdcy8haF36Px4aCipkNU2rxGVrvdFTnfiM7h9K9PyMv9fD17jJfPD4vZ3TKWaUF9nAKwQlQlQIVFmteY5UXehC3b1JUSTDFUFLHOaoaNVFKJGguRNVUOWSaQphOSnXyl7Z2zuOEHq_fCfnAKfIDDW36Cwwc4HBgPcILs9iTD8NtRo-VOagxRlbYoPVe9_q-B7LTRUnQ7_EDX9m_WhNycchcEfDXwH_DTkBhYSdMfJkSHDA |
| CitedBy_id | crossref_primary_10_5200_sm_hs_2013_092 |
| Cites_doi | 10.1016/j.jacc.2009.10.093 10.1378/chest.08-0675 10.1093/eurheartj/ehs169 10.1002/ccd.23172 10.1161/CIRCULATIONAHA.107.740324 10.1056/NEJMoa0908628 10.1161/01.CIR.76.1.142 10.1056/NEJMoa0708191 10.1136/heartjnl-2011-300558 10.1016/j.crvasa.2012.09.001 10.1001/archinte.162.19.2197 10.1056/NEJMoa0706482 10.1016/j.ahj.2010.11.021 10.1136/bmj.c4222 10.1016/S0008-6363(03)00468-1 10.1136/heartjnl-2012-301877b.132 10.1161/CIRCULATIONAHA.108.828541 10.1016/j.amjcard.2010.08.067 10.1056/NEJM199309023291001 10.1161/CIRCULATIONAHA.110.009449 10.1016/j.ahj.2008.08.023 10.1016/j.jacc.2005.09.060 10.1136/hrt.82.3.269 10.1586/ecp.12.19 10.1161/CIRCULATIONAHA.109.927582 10.1016/j.atherosclerosis.2012.02.041 10.1016/S0140-6736(10)61088-4 10.1056/NEJMoa0908629 10.1016/j.jacc.2011.12.045 10.1016/j.jacc.2007.09.003 10.1016/j.ahj.2010.09.029 10.1136/bmj.e4388 10.1016/S0140-6736(96)09457-3 10.1016/S0140-6736(04)16721-4 10.1016/S0140-6736(11)60876-3 10.1016/j.jcin.2009.11.017 10.1001/jama.2012.5034 10.1001/jama.293.14.1759 10.1016/j.amjcard.2011.11.007 10.1016/j.cgh.2012.08.034 10.1056/NEJMoa1205512 10.1016/j.jacc.2012.06.017 10.33678/cor.2009.224 10.1016/j.ahj.2010.07.038 10.1016/j.jcin.2011.02.011 10.1161/CIRCULATIONAHA.111.029165 10.1016/j.jacc.2012.02.042 10.1161/CIRCULATIONAHA.110.002741 10.1016/S0140-6736(11)61872-2 10.1093/eurheartj/ehs215 10.1016/j.jcin.2008.09.011 10.1016/j.crvasa.2011.12.004 10.1016/j.amjcard.2005.06.056 10.1056/NEJMoa0909475 10.2478/v10007-012-0036-8 10.7326/0003-4819-152-1-201001050-00179 10.1016/j.carrev.2008.12.005 10.1016/j.amjcard.2009.06.020 10.1182/blood-2007-10-120543 |
| ContentType | Journal Article |
| Copyright | The Czech Society of Cardiology 2013 The Czech Society of Cardiology |
| Copyright_xml | – notice: The Czech Society of Cardiology – notice: 2013 The Czech Society of Cardiology |
| DBID | 6I. AAFTH AAYXX CITATION |
| DOI | 10.1016/j.crvasa.2013.02.004 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1803-7712 |
| EndPage | e146 |
| ExternalDocumentID | 10_1016_j_crvasa_2013_02_004 S0010865013000271 1_s2_0_S0010865013000271 |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 0SF 1P~ 1~. 1~5 4.4 457 4G. 53G 5RE 7-5 8P~ AACTN AAEDT AAEDW AAIKJ AALRI AAOAW AAXUO ABBQC ABMAC ABMZM ABOCM ABVKL ABXDB ACGFS ACJTP ADBBV ADEZE ADVLN AEKER AEVXI AFCTW AFRHN AGHFR AGUBO AGYEJ AITUG AJOXV AJRQY AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX BLXMC EBS EJD F5P FDB FEDTE FIRID FNPLU GBLVA HVGLF HZ~ M41 MO0 NCXOZ O-L O9- OAUVE OA~ OK1 OL0 P-8 P-9 PC. Q38 ROL SDF SEL SSZ T5K Z5R ZXP ~G- 6I. AAFTH ABYKQ EFLBG LCYCR NAHTW AAYXX CITATION |
| ID | FETCH-LOGICAL-c361t-30026a87008e6359e4565b0084f98da2d2ed1ee9492ebcdcda9e6a4b85044ae13 |
| IEDL.DBID | .~1 |
| ISSN | 0010-8650 |
| IngestDate | Fri Aug 23 04:58:06 EDT 2024 Fri Feb 23 02:33:16 EST 2024 Tue Oct 15 14:34:06 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Antithrombotic treatment ST elevation myocardial infarction Bleeding |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c361t-30026a87008e6359e4565b0084f98da2d2ed1ee9492ebcdcda9e6a4b85044ae13 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0010865013000271 |
| ParticipantIDs | crossref_primary_10_1016_j_crvasa_2013_02_004 elsevier_sciencedirect_doi_10_1016_j_crvasa_2013_02_004 elsevier_clinicalkeyesjournals_1_s2_0_S0010865013000271 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-04-01 |
| PublicationDateYYYYMMDD | 2013-04-01 |
| PublicationDate_xml | – month: 04 year: 2013 text: 2013-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationTitle | Cor et vasa (English ed.) |
| PublicationYear | 2013 |
| Publisher | Elsevier Urban & Partner Sp. z o.o |
| Publisher_xml | – name: Elsevier Urban & Partner Sp. z o.o |
| References | Steg, James, Atar (bib26) 2012; 33 Jolly, Niemela, Xavier, Widimský (bib50) 2011; 161 Bonello, De Labriolle, Roy (bib35) 2009; 10 Mamas, Ratib, Routledge (bib48) 2012; 98 Mehran, Pocock, Nikolsky (bib4) 2011; 4 CAPRIE Steering Commitee. A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE), Lancet 348 (1996) 1329–1339. Rossini, Capodanno, Lettieri (bib60) 2011; 107 Sung, Lau, Ching (bib11) 2010; 152 De Luca, Suryapranata, Stone (bib27) 2005; 293 W. Dewilde, O. Oirbans, F. Verheugt, WOEST trial, ESC Congress, Hotline III, Munchen, August 2012. Fleischer, Beckman, Brown (bib57) 2007; 50 Johnson, Strange, Oriolo (bib2) 2012; 98 Joyal, Bertrand, Rinfret (bib49) 2012; 109 Patel, Patel, Patel, Patel (bib63) 2012; 62 Price, Walder, Baker (bib21) 2012; 59 Arbustini, Dal Bello, Morbini (bib5) 1999; 82 Ben Morrison, Horst, Brown (bib32) 2012; 79 Stone, Witzenbichler, Guagliumi (bib34) 2008; 358 Subherwal, Peterson, Dai (bib41) 2012; 52 Rossini, Capodanno, Lettieri (bib45) 2011; 107 Mehran, Rao, Bhatt (bib40) 2011; 123 Smith, Bleyer, Little, Sane (bib43) 2003; 59 Rao, Bernat, Bertrand (bib46) 2012; 33 Bhatt, Cryer, Contant (bib54) 2010; 363 Chesebro, Knatterud, Roberts (bib37) 1987; 76 Widimsky, Jukema, Meier (bib17) 2012; 54 Mehta, Tanguay, Eikelboom (bib9) 2010; 376 Subherwal, Bach, Chen (bib52) 2009; 119 Gu, Kampinga, Wieringa (bib28) 2010; 122 Wiviott, Trenk, Frelinger (bib19) 2007; 116 Diener, Bogousslavsky, Brass (bib14) 2004; 367 Åkerblom, James, Koutouzis (bib31) 2010; 56 Gregg, Bernhard, Guagliumi (bib33) 2008; 358 Bernat, Rokyta, Koza (bib53) 2009; 51 Mehta, Bassand, Chrolavicius (bib12) 2010; 363 Price, Angiolillo, Teirstein (bib15) 2011; 124 Bhatt, Lincoff, Gibson (bib25) 2009; 361 Douglas, Evans, Hingorani (bib55) 2012; 345 Collet, Cayla, Guisset (bib16) 2001; 161 Montalescot, Zeymer, Silvain (bib36) 2011; 378 De Luca, Verdola, Suryapranta (bib29) 2012; 222 Rao, Grady, Pieper (bib3) 2005; 96 E. Romagnoli, G.B. Zoccai, A. Sciahbasi, et al., Radial Versus Femoral Randomized Investigation in ST Elevation Acute Coronary Syndrome (RIFLE STEACS). Journal of the American College of Cardiology 2012 July 27. Epub ahead of print. The GUSTO Investigators, An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction, The New England Journal of Medicine 329 (1993) 673–682. Steg, James, Robert (bib23) 2010; 122 Thiele, Wohrle, Hambrecht (bib30) 2012; 379 Weisman, Graham (bib8) 2002; 162 Shishehbor, Madhwal, Rajagopal (bib44) 2009; 1 Wiviott, Braunwald, Carolyn (bib20) 2007; 357 Abualsaud, Eisenberg (bib61) 2010; 2 Kallirroi, Tsoumani, Ioannis (bib18) 2012; 5 Jolly, Amlani, Hamon (bib47) 2009; 157 Rao, O'Grady, Pieper (bib39) 2006; 47 J.J. Badimon, B. Ibanez, V. Fuster, et al., Coronary thrombosis local and systematic factors, in: V. Fuster, R.A. Walsh, R.A. Harrington, et al., 13th Edition Hurt's The Heart, 2011, pp. 1225–1227. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), P.G. Steg, S.K. James, D. Atar, et al., ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation, European Heart Journal 33 (2012) 2569–2619. Chassot, Marcucci, Delabays (bib59) 2010; 12 Roe, Armstrong, Fox (bib22) 2012; 367 Harrington, Stone, McNultz (bib24) 2009; 361 Douketis, Berger, Dunn (bib62) 2008; 133 Crowther, Warkentin (bib58) 2008; 111 Derogar, Sandblom, Lundell (bib65) 2013; 11 Widimský, Kala, Rokyta (bib1) 2012; 54 De Berardis, Lucisano, D'Ettorre (bib10) 2012; 307 Manoukian (bib42) 2009; 104 Mauri, Kereiakes, Normand (bib64) 2010; 160 ref13 ref12 ref56 ref15 ref59 ref14 ref58 ref53 ref52 ref11 ref55 ref10 ref17 ref16 ref19 ref18 ref51 Dewilde (ref54) 2012 ref50 ref46 ref45 ref48 ref47 ref42 ref41 ref44 ref43 ref49 ref8 ref7 ref9 ref4 ref3 ref40 ref35 ref34 ref37 ref36 ref31 ref30 ref33 ref32 ref0 ref2 ref1 ref39 ref38 ref24 ref23 ref26 ref25 ref20 ref63 ref22 ref21 Chassot (ref57) 2010; 12 ref28 ref27 ref29 (ref6) 2012; 33 ref60 Badimon (ref5) 2011 ref62 ref61 |
| References_xml | – volume: 107 start-page: 186 year: 2011 end-page: 194 ident: bib60 article-title: Prevalence, predictors and long-term prognosis of premature discontinuation of oral antiplatelet therapy after drug stents implantation publication-title: The American Journal of Cardiology contributor: fullname: Lettieri – volume: 376 start-page: 1233 year: 2010 end-page: 1243 ident: bib9 article-title: Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7) publication-title: Lancet contributor: fullname: Eikelboom – volume: 11 start-page: 38 year: 2013 end-page: 42 ident: bib65 article-title: Discontinuation of low-dose aspirin therapy after peptic ulcer bleeding increases risk of death and acute cardiovascular events publication-title: Clinical Gastroenterology and Hepatology contributor: fullname: Lundell – volume: 161 start-page: 5 year: 2001 end-page: 12 ident: bib16 article-title: Randomized comparison of platelet function monitoring to adjust antiplatelet therapy versus standard of care: (ARCTIC) study publication-title: American Heart Journal contributor: fullname: Guisset – volume: 59 start-page: 2338 year: 2012 end-page: 2343 ident: bib21 article-title: Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease, The RECOVERY trial publication-title: Journal of the American College of Cardiology contributor: fullname: Baker – volume: 47 start-page: 809 year: 2006 end-page: 816 ident: bib39 article-title: A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes publication-title: Journal of the American College of Cardiology contributor: fullname: Pieper – volume: 379 start-page: 923 year: 2012 end-page: 931 ident: bib30 article-title: Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial publication-title: Lancet contributor: fullname: Hambrecht – volume: 104 year: 2009 ident: bib42 article-title: Predictors and impact of bleeding complications in percutaneous coronary intervention, acute coronary syndromes, and ST-segment elevation myocardial infarction publication-title: The American Journal of Cardiology contributor: fullname: Manoukian – volume: 79 start-page: 575 year: 2012 end-page: 582 ident: bib32 article-title: Bridging with glycoprotein IIb/IIIa inhibitors for periprocedural management of antiplatelet therapy in patients with drug eluting stents publication-title: Catheterization and Cardiovascular Interventions contributor: fullname: Brown – volume: 122 start-page: 2131 year: 2010 end-page: 2141 ident: bib23 article-title: A Platelet Inhibition and Patient Outcomes (PLATO) Trial subgroup analysis publication-title: Circulation contributor: fullname: Robert – volume: 162 start-page: 2197 year: 2002 end-page: 2202 ident: bib8 article-title: Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events publication-title: Archives of Internal Medicine contributor: fullname: Graham – volume: 116 start-page: 2923 year: 2007 end-page: 2932 ident: bib19 article-title: Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention, the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation- Thrombolysis in Myocardial Infarction 44 trial publication-title: Circulation contributor: fullname: Frelinger – volume: 122 start-page: 2709 year: 2010 end-page: 2717 ident: bib28 article-title: Intracoronary versus intravenous administration of abciximab in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with thrombus aspiration: the comparison of intracoronary versus intravenous abciximab administration during emergency reperfusion of ST-segment elevation myocardial infarction (CICERO) trial publication-title: Circulation contributor: fullname: Wieringa – volume: 76 start-page: 142 year: 1987 end-page: 154 ident: bib37 article-title: Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge publication-title: Circulation contributor: fullname: Roberts – volume: 33 start-page: 251 year: 2012 end-page: 256 ident: bib46 article-title: Remaining challenges and opportunities for improvement in percutaneous transradial coronary procedures publication-title: European Heart Journal contributor: fullname: Bertrand – volume: 111 start-page: 4871 year: 2008 end-page: 4879 ident: bib58 article-title: Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents publication-title: Blood contributor: fullname: Warkentin – volume: 124 start-page: 1132 year: 2011 end-page: 1137 ident: bib15 article-title: Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial publication-title: Circulation contributor: fullname: Teirstein – volume: 160 start-page: 1035 year: 2010 end-page: 1041 ident: bib64 article-title: Ratisonale and design of the dual antiplatelet therapy study, a prospective, multicenter, randomized, double-blind trial to assess the effectiveness and safety of 12 versus 30 months of dual antiplatelet therapy in subjects undergoing percutaneous coronary intervention with either drug-eluting stent or bare metal stent placement for the treatment of coronary artery lesions publication-title: American Heart Journal contributor: fullname: Normand – volume: 52 start-page: 1861 year: 2012 end-page: 1869 ident: bib41 article-title: Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry publication-title: Journal of the American College of Cardiology contributor: fullname: Dai – volume: 363 start-page: 1909 year: 2010 end-page: 1917 ident: bib54 article-title: COGENT trial, Clopidogrel with or without omeprazole in coronary artery disease publication-title: The New England Journal of Medicine contributor: fullname: Contant – volume: 98 start-page: 303 year: 2012 end-page: 311 ident: bib48 article-title: Influence of access site selection on PCI-related adverse events in patients with STEMI: meta-analysis of randomised controlled trials publication-title: Heart contributor: fullname: Routledge – volume: 152 start-page: 1 year: 2010 end-page: 9 ident: bib11 article-title: Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial publication-title: Annals of Internal Medicine contributor: fullname: Ching – volume: 54 start-page: e32 year: 2012 end-page: e38 ident: bib17 article-title: Evolving strategies in the management of acute coronary syndromes with oral antiplatelet agents publication-title: Cor et Vasa contributor: fullname: Meier – volume: 367 start-page: 1297 year: 2012 end-page: 1309 ident: bib22 article-title: Prasugrel versus clopidogrel for acute coronary syndromes without revascularization publication-title: The New England Journal of Medicine contributor: fullname: Fox – volume: 5 start-page: 319 year: 2012 end-page: 336 ident: bib18 article-title: Pharmacodynamic properties of antiplatelet agents, current knowledge and future perspectives publication-title: Expert Review of Clinical Pharmacology contributor: fullname: Ioannis – volume: 358 start-page: 2218 year: 2008 end-page: 2230 ident: bib34 article-title: The HORIZONS-AMI Trial Investigators Bivalirudin during primary PCI in acute myocardial infarction publication-title: The New England Journal of Medicine contributor: fullname: Guagliumi – volume: 109 start-page: 813 year: 2012 end-page: 818 ident: bib49 article-title: Meta-analysis of ten trials on the effectiveness of the radial versus the femoral approach in primary percutaneous coronary intervention publication-title: American Journal of Cardiology contributor: fullname: Rinfret – volume: 363 start-page: 930 year: 2010 end-page: 942 ident: bib12 article-title: The CURRENT-OASIS 7 publication-title: The New England Journal of Medicine contributor: fullname: Chrolavicius – volume: 1 start-page: 46 year: 2009 end-page: 53 ident: bib44 article-title: Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction publication-title: Journal of the American College of Cardiology, Cardiovascular Interventions contributor: fullname: Rajagopal – volume: 62 start-page: 473 year: 2012 end-page: 496 ident: bib63 article-title: Current status and future prospects of drug eluting stents for restenosis publication-title: Acta Pharmaceutica contributor: fullname: Patel – volume: 4 start-page: 654 year: 2011 end-page: 664 ident: bib4 article-title: Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials publication-title: Journal of the American College of Cardiology, Cardiovascular Interventions contributor: fullname: Nikolsky – volume: 59 start-page: 538 year: 2003 end-page: 548 ident: bib43 article-title: The cardiovascular effects of erythropoietin publication-title: Cardiovascular Research contributor: fullname: Sane – volume: 161 start-page: 254 year: 2011 end-page: 260 ident: bib50 article-title: Rival trial. Design and rationale of the radial versus femoral access for coronary intervention publication-title: American Heart Journal contributor: fullname: Widimský – volume: 133 start-page: 299S year: 2008 end-page: 339S ident: bib62 article-title: The perioperative management of antithrombotic therapy, American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition) publication-title: Chest contributor: fullname: Dunn – volume: 96 start-page: 1200 year: 2005 end-page: 1206 ident: bib3 article-title: Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes publication-title: American Journal of Cardiology contributor: fullname: Pieper – volume: 358 start-page: 2218 year: 2008 end-page: 2230 ident: bib33 article-title: The HORIZONS-AMI trial investigators. Bivalirudin during primary PCI in acute myocardial infarction publication-title: The New England Journal of Medicine contributor: fullname: Guagliumi – volume: 123 start-page: 2736 year: 2011 end-page: 2747 ident: bib40 article-title: Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium publication-title: Circulation contributor: fullname: Bhatt – volume: 119 start-page: 1873 year: 2009 end-page: 1882 ident: bib52 article-title: Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE Bleeding Score publication-title: Circulation contributor: fullname: Chen – volume: 12 start-page: 1484 year: 2010 end-page: 1489 ident: bib59 article-title: Perioperative antiplatelet therapy publication-title: American Family Physician contributor: fullname: Delabays – volume: 293 start-page: 1759 year: 2005 end-page: 1765 ident: bib27 article-title: Abciximab as adjunctive therapy to reperfusion in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized trials publication-title: The Journal of the American Medical Association contributor: fullname: Stone – volume: 345 start-page: e4388 year: 2012 ident: bib55 article-title: Clopidogrel and interaction with pump inhibitors: comparison between cohort and within person study designs publication-title: British Medical Journal contributor: fullname: Hingorani – volume: 367 start-page: 331 year: 2004 end-page: 337 ident: bib14 article-title: Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH) publication-title: Lancet contributor: fullname: Brass – volume: 378 start-page: 693 year: 2011 end-page: 703 ident: bib36 article-title: ATOLL trial of enoxaparine in primary percutaneus coronary intervention publication-title: Lancet contributor: fullname: Silvain – volume: 307 start-page: 2286 year: 2012 end-page: 2294 ident: bib10 article-title: Association of aspirin use with major bleeding in patients with and without diabetes publication-title: The Journal of the American Medical Association contributor: fullname: D'Ettorre – volume: 361 start-page: 2330 year: 2009 end-page: 2341 ident: bib25 article-title: Intravenous platelet blockade with cangrelor during PCI publication-title: The New England Journal of Medicine contributor: fullname: Gibson – volume: 10 start-page: 156 year: 2009 end-page: 161 ident: bib35 article-title: Head-to-head comparison of bivalirudin versus heparin without glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction undergoing primary angioplasty publication-title: Cardiovascular Revascularization Medicine contributor: fullname: Roy – volume: 56 start-page: 476 year: 2010 end-page: 478 ident: bib31 article-title: Eptifibatide is noninferior to abciximab in primary percutaneous coronary intervention: results from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) publication-title: Journal of the American College of Cardiology contributor: fullname: Koutouzis – volume: 82 start-page: 269 year: 1999 end-page: 272 ident: bib5 article-title: Plague erosion is a major substrate for coronary thrombosis in acute myocardial infarction publication-title: Heart contributor: fullname: Morbini – volume: 51 start-page: 59 year: 2009 end-page: 63 ident: bib53 article-title: Radiální přístup u koronárních a nekoronárních katetrizací a intervencí publication-title: Cor et Vasa contributor: fullname: Koza – volume: 357 start-page: 2001 year: 2007 end-page: 2015 ident: bib20 article-title: Prasugrel versus clopidogrel in patients with acute coronary syndromes publication-title: The New England Journal of Medicine contributor: fullname: Carolyn – volume: 361 start-page: 2318 year: 2009 end-page: 2329 ident: bib24 article-title: Platelet inhibition with cangrelor in patients undergoing PCI publication-title: The New England Journal of Medicine contributor: fullname: McNultz – volume: 157 start-page: 132 year: 2009 end-page: 140 ident: bib47 article-title: Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials publication-title: American Heart Journal contributor: fullname: Hamon – volume: 98 start-page: 74 year: 2012 end-page: 75 ident: bib2 article-title: Collected resources: percutaneous intervention publication-title: Heart contributor: fullname: Oriolo – volume: 222 start-page: 426 year: 2012 end-page: 433 ident: bib29 article-title: Benefits from intracoronary as compared to intravenous abciximab administration for STEMI patients undergoing primary angioplasty: a meta-analysis of 8 randomized trials publication-title: Atherosclerosis contributor: fullname: Suryapranta – volume: 54 start-page: e273 year: 2012 end-page: e289 ident: bib1 article-title: Summary of the 2012 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST elevations publication-title: Cor et Vasa contributor: fullname: Rokyta – volume: 2 start-page: 131 year: 2010 end-page: 142 ident: bib61 article-title: Perioperative management of patients with drug-eluting stents publication-title: Journal of the American College of Cardiology, Cardiovascular Interventions contributor: fullname: Eisenberg – volume: 33 start-page: 2569 year: 2012 end-page: 2619 ident: bib26 article-title: Acute myocardial infarction in patients with ST segment elevation publication-title: European Heart Journal contributor: fullname: Atar – volume: 107 start-page: 186 year: 2011 end-page: 194 ident: bib45 article-title: Prevalence, predictors, and long-term prognosis of premature discontinuation of oral antiplatelet therapy after drug eluting stent publication-title: The American Journal of Cardiology contributor: fullname: Lettieri – volume: 50 start-page: 159 year: 2007 end-page: 241 ident: bib57 article-title: ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery publication-title: Journal of the American College of Cardiology contributor: fullname: Brown – ident: ref29 doi: 10.1016/j.jacc.2009.10.093 – ident: ref60 doi: 10.1378/chest.08-0675 – ident: ref44 doi: 10.1093/eurheartj/ehs169 – volume: 12 start-page: 1484 year: 2010 ident: ref57 article-title: Perioperative antiplatelet therapy publication-title: American Family Physician contributor: fullname: Chassot – ident: ref30 doi: 10.1002/ccd.23172 – ident: ref18 doi: 10.1161/CIRCULATIONAHA.107.740324 – ident: ref23 doi: 10.1056/NEJMoa0908628 – ident: ref35 doi: 10.1161/01.CIR.76.1.142 – ident: ref32 doi: 10.1056/NEJMoa0708191 – ident: ref46 doi: 10.1136/heartjnl-2011-300558 – ident: ref0 doi: 10.1016/j.crvasa.2012.09.001 – ident: ref7 doi: 10.1001/archinte.162.19.2197 – ident: ref19 doi: 10.1056/NEJMoa0706482 – ident: ref48 doi: 10.1016/j.ahj.2010.11.021 – ident: ref52 doi: 10.1136/bmj.c4222 – ident: ref41 doi: 10.1016/S0008-6363(03)00468-1 – ident: ref1 doi: 10.1136/heartjnl-2012-301877b.132 – ident: ref50 doi: 10.1161/CIRCULATIONAHA.108.828541 – ident: ref58 doi: 10.1016/j.amjcard.2010.08.067 – ident: ref36 doi: 10.1056/NEJM199309023291001 – ident: ref38 doi: 10.1161/CIRCULATIONAHA.110.009449 – ident: ref45 doi: 10.1016/j.ahj.2008.08.023 – ident: ref37 doi: 10.1016/j.jacc.2005.09.060 – ident: ref4 doi: 10.1136/hrt.82.3.269 – ident: ref17 doi: 10.1586/ecp.12.19 – ident: ref22 doi: 10.1161/CIRCULATIONAHA.109.927582 – ident: ref27 doi: 10.1016/j.atherosclerosis.2012.02.041 – ident: ref8 doi: 10.1016/S0140-6736(10)61088-4 – ident: ref24 doi: 10.1056/NEJMoa0908629 – ident: ref39 doi: 10.1016/j.jacc.2011.12.045 – ident: ref55 doi: 10.1016/j.jacc.2007.09.003 – ident: ref15 doi: 10.1016/j.ahj.2010.09.029 – ident: ref53 doi: 10.1136/bmj.e4388 – ident: ref12 doi: 10.1016/S0140-6736(96)09457-3 – ident: ref13 doi: 10.1016/S0140-6736(04)16721-4 – ident: ref34 doi: 10.1016/S0140-6736(11)60876-3 – ident: ref59 doi: 10.1016/j.jcin.2009.11.017 – ident: ref9 doi: 10.1001/jama.2012.5034 – ident: ref25 doi: 10.1001/jama.293.14.1759 – ident: ref43 doi: 10.1016/j.amjcard.2010.08.067 – ident: ref47 doi: 10.1016/j.amjcard.2011.11.007 – ident: ref63 doi: 10.1016/j.cgh.2012.08.034 – ident: ref21 doi: 10.1056/NEJMoa1205512 – ident: ref49 doi: 10.1016/j.jacc.2012.06.017 – ident: ref51 doi: 10.33678/cor.2009.224 – ident: ref62 doi: 10.1016/j.ahj.2010.07.038 – ident: ref31 doi: 10.1056/NEJMoa0708191 – volume-title: Hurt's The Heart, 13th edition year: 2011 ident: ref5 article-title: Coronary thrombosis local and systematic factors contributor: fullname: Badimon – ident: ref3 doi: 10.1016/j.jcin.2011.02.011 – ident: ref14 doi: 10.1161/CIRCULATIONAHA.111.029165 – ident: ref20 doi: 10.1016/j.jacc.2012.02.042 – ident: ref26 doi: 10.1161/CIRCULATIONAHA.110.002741 – ident: ref28 doi: 10.1016/S0140-6736(11)61872-2 – volume: 33 start-page: 2569 year: 2012 ident: ref6 article-title: Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), P.G. Steg, S.K. James, D. Atar, et al., ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation publication-title: European Heart Journal doi: 10.1093/eurheartj/ehs215 – volume-title: WOEST trial, ESC congress, Hotline III, Munchen, August year: 2012 ident: ref54 contributor: fullname: Dewilde – ident: ref42 doi: 10.1016/j.jcin.2008.09.011 – ident: ref16 doi: 10.1016/j.crvasa.2011.12.004 – ident: ref2 doi: 10.1016/j.amjcard.2005.06.056 – ident: ref11 doi: 10.1056/NEJMoa0909475 – ident: ref61 doi: 10.2478/v10007-012-0036-8 – ident: ref10 doi: 10.7326/0003-4819-152-1-201001050-00179 – ident: ref33 doi: 10.1016/j.carrev.2008.12.005 – ident: ref40 doi: 10.1016/j.amjcard.2009.06.020 – ident: ref56 doi: 10.1182/blood-2007-10-120543 |
| SSID | ssj0000627011 |
| Score | 1.9129016 |
| SecondaryResourceType | review_article |
| Snippet | Abstract The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100 000 of population/year, with 6–12% hospital mortality in... The incidence of ST elevation myocardial infarction (STEMI) is around 66 STEMI per 100000 of population/year, with 6–12% hospital mortality in unselected... |
| SourceID | crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | e135 |
| SubjectTerms | Antithrombotic treatment Bleeding Cardiovascular ST elevation myocardial infarction |
| Title | STEMI—The importance of balance between antithrombotic treatment and bleeding risk |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0010865013000271 https://dx.doi.org/10.1016/j.crvasa.2013.02.004 |
| Volume | 55 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELaqDogF8RTlJQ-soXEebjyiiqpCgoVW6mbZsSOKaFM1hRHxI_iF_BLuHKcqAjGwRUmcOGf7HvH33RFyyZTmGStEANaPIyWHB0prG2jDtDZc9Kwj0t7d8-E4uZ2kkxbpN1wYhFV63V_rdKet_Zmul2Z3MZ0ixxerBKW49YbBlWOwp25xXr2x9X8WTMMbsrpwHqgcbNAw6BzMK1--qgoTELG4Tt6Z_G6hNqzOYJfseHeRXtc92iMtO98nW3d-Q_yAjB5GIMjP9w8YbjqdOWcaPoGWBdUIWoRDj8SiCgm5j8typkt4GF0jzOGCofq5tmIUoeaHZDy4GfWHgS-UEOQxZ6sgxkhKwcoLMwsOhLDopmlMlV-IzKjIRNYwa0UiIqtzkxslLFeJztIwSZRl8RFpz8u5PSaUFVZgGUeuwVPihmeJwqgKgjqVZkJHHRI0wpGLOh-GbIBiT7IWpkRhyjCSIMwO6TUSlA3XE7STrfxSqSSTFdwpfwznZstvM0KCsv_znSf_bnlKtiNX7gKROWekvVq-2HNwOlb6ws2qLwiB1F4 |
| link.rule.ids | 315,783,787,4511,27938,27939,45599 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwELUqkIALYhVl9YFraJwmbnxEFVWBthdSqTfLjh1RRJuqKRwRH8EX8iXMZKmKQBy4RUmcOGN7lvi9GUIumdI8ZIlwwPpxpORwR2ltHW2Y1oaLls2JtP0B7w79u1EwqpF2xYVBWGWp-wudnmvr8kyjlGZjNh4jxxerBAW49YbBFYRA6z7mz4JJffXGlj9aMA-vy4rKeaBzsEVFoctxXvH8VWWYgYg1i-yd_u8masXsdHbIdukv0uuiS7ukZqd7ZKNf7ojvk-ghAkl-vn_AeNPxJPem4RtomlCNqEU4LKFYVCEj93GeTnQKD6NLiDlcMFQ_F2aMItb8gAw7N1G765SVEpy4ydnCaWIopWDpuaEFD0JY9NM05spPRGiUZzxrmLXCF57VsYmNEpYrX4eB6_vKsuYhWZumU3tEKEuswDqOXIOrxA0PfYVhFUR1KgiF9urEqYQjZ0VCDFkhxZ5kIUyJwpSuJ0GYddKqJCgrsieoJ5uVayWTTGZwp_wxnqstv00JCdr-z3ce_7vlBdnsRv2e7N0O7k_IlpfXvkCYzilZW8xf7Bl4IAt9ns-wL-tc144 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=STEMI+-+The+importance+of+balance+between+antithrombotic+treatment+and+bleeding+risk&rft.jtitle=Cor+et+vasa+%28English+ed.%29&rft.au=Posp%C3%AD%C5%A1il%2C+Jan&rft.au=Hrom%C3%A1dka%2C+Milan&rft.au=Bernat%2C+Ivo&rft.au=Rokyta%2C+Richard&rft.date=2013-04-01&rft.issn=0010-8650&rft.eissn=1803-7712&rft.volume=55&rft.issue=2&rft.spage=e135&rft.epage=e146&rft_id=info:doi/10.1016%2Fj.crvasa.2013.02.004&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_crvasa_2013_02_004 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0010-8650&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0010-8650&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0010-8650&client=summon |