Time course and quantitative analysis of the adaptive responses to 85% oxygen in the rat lung and heart

• Published in: Biochimica et biophysica acta Vol. 1523; no. 2-3; pp. 209 - 216
• Main Authors: Evelson, Pablo, González-Flecha, Beatriz
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 18.10.2000
• Subjects: Aconitate Hydratase - metabolism; Animals; Antioxidant; Edema; Enzyme Induction; Heart - drug effects; Heart - physiology; Hyperoxia; Kinetics; Liver - drug effects; Liver - physiology; Luminescent Measurements; Lung - drug effects; Lung - physiology; Male; Oxidative Stress; Oxygen - toxicity; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Superoxide Dismutase - biosynthesis; Superoxides - metabolism; Thiobarbituric Acid Reactive Substances - analysis; Time Factors; Oxidative stress; Reactive oxygen species; Antioxidant; Hyperoxia

The phenomenon of oxygen tolerance (resistance to 100% O2 in rats previously exposed to 85% O2) constitutes one of the few models of adaptive responses to oxidative stress in mammals. In vitro studies suggest that reactive oxygen species mediate this response. To test this hypothesis in vivo, we fol...